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Hashtag
#TryptophanWednesday
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This too is #TryptophanWednesday
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Four line diagrams of protein chunks, featuring tryptophan, an amino acid with a five-atom ring next to a six-atom ring. In most pictures, tryptophan is dark green, except for the third picture (in which tryptophan is blue). The first three pictures also feature DNA (yellow in the first two pictures, red and yellow in the third picture). The protein chunks have the following Protein Data Bank IDs: 7D3X (1), 7DTA (2 & 3), and 8CIQ (4).
It's been hard to bring myself to post my little #TryptophanWednesday squiggles in times of extreme senselessness and national self-sabotage.
However,
...
.....
....really thought I'd come up with a way to finish that sentence if I just started it...
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Oh! Right! It's still #TryptophanWednesday on the west coast, at least...!
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A line diagram of a chunk of a protein (8RD6, linked in the post). Tryptophan is the bulky orange side chain in the center-right, and methionine is the long hook-like orange one to its upper left. Proline is the blue five-atom ring on their left. Multiple conformers are laid on top of each other, so the overall image is messy and sketchlike.
#TryptophanWednesday: Again--something about this that just hits my eyeballs right good.
Tryptophan and methionine being bros, with proline in the background.
www.rcsb.org/3d-view/8RD6
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A line diagram of a protein chunk (2GLO, linked in the post). Tryptophan is the dark green amino acid; behind it in dark orange is lysine, and to their right is a medium green phenylalanine. Multiple conformers are laid on top of each other, so the image looks a bit sketchy and messy in a way that hits my eyeballs just right.
#TryptophanWednesday - something about this one I just *like*.
www.rcsb.org/3d-view/2GLO
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Two line diagrams of a chunk of a protein. Multiple conformers are laid on top of each other, so it looks kind of messy and sketch-like. In the first picture, many colorful amino acids are shown, including histidine (purple ring, bottom left), phenylalanine (gray ring, right), and tryptophan (gold partially-cut-off rings, top left). In the second picture, the same protein chunk is shown from a slightly different angle, featuring three phenylalanine bits.
#TryptophanWednesday!
www.rcsb.org/3d-view/8BXJ
(Okay, the second picture barely shows any tryptophan, I just like it)
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A line diagram, without hydrogens, of a chunk of protein bound to a chunk of RNA (PDB ID 1A1T: https://www.rcsb.org/3d-view/1A1T/0 ). Multiple conformers are laid on top of each other, so the lines are kind of fuzzy. Tryptophan is the orange amino acid on the left. The next two pictures show the same structure, in different colors/at different angles.
#TryptophanWednesday; I only really like one of these, but which one that is changes regularly, so...
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A screenshot of a line diagram of a chunk of protein--PDB ID 1G4D: https://www.rcsb.org/structure/1g4d Tryptophan is the amino acid in dark gold. Multiple conformers are laid on top of each other, so it has a messy sketch-like feel to it.
#TryptophanWednesday: now with more splotches!
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Four line diagrams, at different angles and using different coloring schemes, of PDB entry 7SJL (a chunk of a protein called neuregulin-1; a chunk which is immunoglobulin-like). Tryptophan is the amino acid that is dark green in the first two pictures. Multiple conformers are laid on top of each other, so it looks kind of chaotic, like a photo with a long exposure time where someone moved. The first picture shows hydrogens, while the other three do not. The first two pictures are colored by hydrophobicity, while the last two are colored by sequence.
#TryptophanWednesday: look at these little weirdos!
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A line diagram of PDB entry 2KY8, showing a chunk of protein bound to a chunk of DNA. Tryptophan is in the center, a dark gold-ish amino acid bearing a six-carbon ring next to a five-atom ring. It is a solution NMR structure, with multiple conformers laid on top of each other, so it has a messy sketch-like feel to it.
Another one of my favorite little chaos nuggets for #TryptophanWednesday
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Two line diagrams of a protein chunk bound to a DNA chunk (PDB ID 1TF3). The two images are the same, except for color; in the first image, DNA is light green, lysine is orange, and tryptophan's rings are dark green. It is a solution NMR structure, with multiple conformers laid on top of each other, so it has a messy sketch-like feel to it.
For morale: tryptophan, two lysine, DNA
#TryptophanWednesday
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Three pairs of earring-sized plastic tryptophan models. Each pair consists of L-tryptophan (left) and D-tryptophan (right). All pairs have hydrogens shown in light green and nitrogen shown in light blue. One pair has dark purple carbon and orange oxygen; another pair has magenta carbon and silver oxygen; and the third pair has hot pink carbon and light purple oxygen.
#TryptophanWednesday: the next enantiomearrings are, of course, trippy tryptophan.
Still dialing in the colors; it needs to be...trippier.
Luckily, it's a quick print, so it's easy to run tests between the day prints and the overnight prints. #NightScience indeed.
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A close-up picture of a plastic sodium channel model. A jungle gym of orange angular spirals (the carbon backbone) surrounds a few side chains, plus a tetrodotoxin molecule, which are shown in spacefill (in which the gray atoms are carbon, the red ones are oxygen, and the blue ones are nitrogen). Tryptophan is the side chain in the top left, the one with a six-atom ring next to a five-atom ring.
A screenshot from a phone using the sodium channel's AR function. When the phone is pointed at the model, it adds an animation of sodium ions (and their watery escorts) entering the sodium channel (in the absence of tetrodotoxin).
A gloved hand holding a tetrodotoxin model.
#TryptophanWednesday! This is one of my favorite models. It's a sodium channel, mostly backbone, with some side chains shown due to their role in binding tetrodotoxin.
This isn't an ad, but, like, I'm not gonna *not* tell you where to get one...: shop.3dmoleculardesigns.com/products/mig...
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Four line diagrams, at different angles, of PDB entry 1TN9 (an integrase chunk bound to a DNA chunk). Multiple conformers are laid on top of each other, so it looks kind of chaotic, like a photo with a long exposure time where someone moved. Tryptophan is the dark gold amino acid. In the third picture, the structure's hydrogens are shown.
That first one looks like I feel
#TryptophanWednesday
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Sixteen grape-sized 3D-printed tryptophan models, with elongated and magnetized nitrogens for easy bonding, lined up in a row.
Sometimes I like to stay at work late...and play with the magnets...
#TryptophanWednesday
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“How Tryptophane Was Discovered” gave an offhand account of one of Hopkins’s signature achievements: “H. said: ‘Let’s discover tryptophane.’ And C. [Sydney Cole, Hopkins’s assistant] said: ‘Oh, all right, I’ve got nothing to do just now, let’s.’"
#TryptophanWednesday
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Happy #TryptophanWednesday!
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Line diagrams of protein chunks bound to RNA or DNA chunks. All are solution NMR structures, with multiple conformers laid on top of each other, so it has a messy sketch-like feel to it. They are cluttered and 'meh' in many ways, and I am actively working on not letting that stop me from sharing them. Tryptophan is the amino acid with a five-atom ring next to a six-atom ring; it's dark greenish-gold, except in the third picture, where it's dark green. The first two pictures show PDB ID 1QFQ, the third shows 8R1X, and the fourth shows 1G4D.
Happy #TryptophanWednesday!
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Four line diagrams of a protein chunk (PDB ID 8Q5B, an archeal zinc finger). The focus is on tryptophan, an amino acid that has a five-carbon ring attached to a six-carbon ring. Multiple conformers are laid on top of each other; in some conformers, the tryptophan is shown with the six-carbon ring on one side, while in some conformers, the six-carbon ring is facing the other way. It looks very messy, because it is. The first picture shows tryptophan in yellow, and the next three show tryptophan in red. In the last picture, hydrogen atoms are also shown.
Happy #TryptophanWednesday 😜
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