Graphical abstract divided into two halves labeled “Physical” and “Biological,” centered around a large cancer cell illustration. Left (Physical properties): Mechanical factors such as ECM stiffness and cell viscosity increase during tumor progression. Diagrams illustrate low, mid, and high electrical frequencies (impedance profiling), along with thermal gradients and solid stress within the tumor microenvironment. Right (Biological consequences): Physical properties are linked to cancer stem cell enrichment, stemness, metastatic potential, and therapy resistance. Icons show a stem cell cluster, metastatic cell invasion through epithelial layers, radiation and drug resistance, and immune interactions. The figure emphasizes that tumor physical parameters and biological hallmarks are interconnected and mutually reinforcing, contributing to heterogeneity and clinical outcomes.

📘 CHP Archive Spotlight #10
Review (2024) | Markl et al.
Cancer is not only molecular — it is physical.
Tumors reflect:
• Stiffness & ECM remodeling
• Cell mechanics
• Electrical/thermal states
• Solid stress
Biophysics shapes heterogeneity.
🔗 doi.org/10.47248/chp...
#TumorBiophysics #Mechanobiology