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ddx R. #typhi is spread when flea feces are rubbed into skin wounds. This is a mild illness, is seen most often in refugee camps and areas of poverty, but is seen domestically, mostly in California, Texas, Hawaii in USA so this pt doesnt fit geographically

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Special congratulations for Allan Zuza here for his first first-author 🎉 and Alexander Wailan for being the first to spot that something was looking funny with a few isolates!!! Many thanks as always to Nick Feasey who led the #Typhi work in #Malawi this dives into.

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Gates Open Research Article: An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids. Read the latest article version by Allan Zuza, Alexander M. Wailan, Catherine Anscombe, Nicholas A. Feasey, Eva Heinz, at Gates Open Research.

And if you actually took Xmas off (well done!!!), #Typhi #AMR #plasmids #genomics and a reminder that there is so much more under the hood in large-scale genome data beyond the first large-scale analysis, it pays off to keep digging 💻🧬🧪🦠
gatesopenresearch.org/articles/8-143

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Preview
Investigation of an ongoing outbreak of ceftriaxone-resistant Salmonella enterica serovar Typhi in Bangladesh We report an outbreak of ceftriaxone-resistant Salmonella Typhi in Bangladesh, with 47 cases identified from April-September 2024. Isolates belong to genotype 4.3.1.2 and harbor the blaCTX-M-15 gene o...

1/ Outbreaks don't stop during holidays. #Surveillance is year-round work and here is an urgent report on an ongoing outbreak of ceftriaxone-resistant #Salmonella #Typhi in Bangladesh.
📄 Findings: www.medrxiv.org/content/10.1... 🧵

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Gates Open Research Article: An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids. Read the latest article version by Allan Zuza, Alexander M. Wailan, Catherine Anscombe, Nicholas A. Feasey, Eva Heinz, at Gates Open Research.

Will do shout-out when everyone's back, but for all still online, please look at Allan Zuza's first first-author paper! #Malawi #Typhi #AntimicrobialResistance. Many thanks to the reviewers for super helpful comments (review history on verixiv) 😊 🧬💻 gatesopenresearch.org/articles/8-1...

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Five years of GenoTyphi: updates to the global Salmonella... In 2016 a whole genome sequence (WGS) based genotyping fr...

Five years of GenoTyphi: updates to the global Salmonella Typhi genotyping framework

with some beautiful figures, of course, by @msmicrobiocode & @DrKatHolt

#Salmonella #Typhi
www.biorxiv.org/content/10.1101/2021.04....

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