Neurodegenerative disease in C9orf72 repeat expansion carriers: population risk and effect of UNC13A The C9orf72 hexanucleotide repeat expansion is associated with ALS and certain forms of dementia, though its exact penetrance remains unclear. In a UK popu

New paper out from Jiali and team. Using @ukbiobank.bsky.social data, we quantified how #ALS and #dementia incidence increase with age in carriers of #C9orf72 expansion, and demonstrated that a common #UNC13A variant nearly doubles disease risk. #ALS #MND #FTD. academic.oup.com/brain/articl...