Activating HIF1α to⏫Endothelialization of SilkFibroin/PCL #VascularGraft

PLGA Nanoparticle
+ML228 HIF activator
+Platelet membrane camouflage

>10 Mpa tensile stress ~naive coronary artery
>80 Mpa Young's modulus ~50-fold naive vessel

Rat aorta implants 3 mo

www.sciencedirect.com/science/arti...

Heparin and zwitterion functionalized small-diameter vascular grafts for thrombogenesis prevention Vascular transplantation is a widely employed surgical approach for treating cardiovascular diseases (CVDs). However, artificial vascular grafts exhibit high thrombogenicity. Consequently, developing…

The double-layered heparin- & zwitterion-functionalized electrospun vascular graft (PCLH/SBPU20) exhibits strong #AntiThrombotic, #AntiCoagulant, & #biocompatible properties, making it a promising candidate for clinical #VascularGraft applications.

#OpenAccess:

MEW/PVA‐MA Hydrogel Vascular Grafts: Enhancing Hemocompatibility and Endothelialization A biomimetic vascular graft combining biofunctionalized PVA-MA hydrogels with a MEW scaffold is developed for small-diameter applications. Gel-MA and Hep-MA incorporation enhances endothelialization ...

New publication!
A novel biomimetic approach by combining PVA-MA-based hydrogels with #MEW scaffolds, creating a customizable #vasculargraft where the #hydrogels offer potential as ECM for cell attachment while the MEW scaffolds provide reinforcement
advanced.onlinelibrary.wiley.com/doi/10.1002/...