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Comprehensive investigation of SARS-CoV-2 intestinal pathogenesis in Drosophila
EL KAMALI, L., NAGY, P., GIRARD, J., BUCHON, N., MAVINGUI, P., EL KALAMOUNI, C., OSMAN, D.
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#SARSCoV2Research #DrosophilaStudy #ViralPathogenesis
#BetaHPV49, linked to skin cancer, uses a splice site in E6 previously seen only in #highrisk alpha-HPV. This site regulates E6 levels and is essential for keratinocyte immortalisation, revealing similarities in #viralpathogenesis.
Read the paper 👉https://bit.ly/4dTHST5
#IPVSPaperOfTheWeek
Dimensions of an R-loop structure relative to RNA polymerase I| (RNAPII), and its relevance to viral and host genomes. An R-loop forms when RNA hybridizes with the complementary DNA strand, typically spanning hundreds of base pairs, although in some genomic contexts, R-loops can extend up to 2 kilobases (kb) in length. This corresponds to a possible range from ~34 nanometers (nm) to over 600nm. These structures can arise in both viral and host genomes and are characterized by similar biochemical features and dependence on comparable enzymatic machinery. For spatial context, the RNA Polymerase I| (RNAPII) core enzyme has a compact structure with a length of around 15nm and a height of 8 to 10nm. The holoenzyme, which includes additional transcription factors such as Mediator and TFIIH, exceeds 40nm in size and has a molecular mass greater than 2 megadaltons (MDa). Within the RNAPII complex, the transcription bubble spans ~ 10nm, with DNA entry and exit channels measuring ~2m and the RNA exit channel slightly wider at ~ 3nm. These structural comparisons highlight the physical scale of R-loops relative to the transcription machinery in both host and viral contexts.
#Medsky🧪 #Immunosky #IDSky #publichealth #Microsky #Biology & Evolution of viruses . Intriguing research on the roles of R loops in #viralpathogenesis, latency & reactivation; explores how viruses harness or evade R Loop associated responses
