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Client Article | Neuron | Prof. Jingdun Xie’s Team at Sun Yat-sen University Decodes PDAC Comorbidity: How the Tumor–Metabolism–Neuron Axis Drives Pain and Depression This study reveals how tumor-derived SAM and METTL14-driven m⁶A modification rewire LPBN neural circuits to drive pain–depression comorbidity in PDAC.

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A new study reveals a tumor–metabolite–neuron axis in pancreatic #cancer. Tumor-derived SAM and METTL14-mediated m⁶A modification drive LPBN neural hyperexcitability and pain–depression comorbidity
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