Single-cell analyses reveal #VascularEndothelialCells act as non-professional #phagocytes in #Atherosclerosis, where #SRB1 drives apoptotic debris uptake via #adherensjunction and cytoskeleton remodeling, uncovering a novel clearance pathway.

#OpenAccess: doi.org/10.1016/j.ge...

BIOLOGY TAKEAWAY: We proposed a catenin phospho-code—where combinatorial phosphorylation of these large proteoforms works with mechanical signals to drive cadherin–catenin organization and #adherensjunction function. (6/7)

α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure This paper shows how epithelial cell–cell junctions play a critical role in the fidelity of cell division, where persistent unfolding of the mechanosensiti

AT LONG LAST… The essential #adherensjunction mechanosensitive protein alpha-catenin is required for #cytokinesis fidelity. We credential a previously defined (but poorly understood) abscission factor in this process, LZTS2. 🧵 1/12 rupress.org/jcb/article-...