To date, a wide spectrum of efforts have explored the design of osteogenic or osseoinductive biomaterials such as polymers, metals, and ceramics. Increasingly, efforts have also explored alternative fabrication approaches to create patient-specific implants. These efforts include adaptation of generative design principles and 3D printing to create unique geometries, methods to incorporate exogenous cell sources, and the use of conventional and exotic growth factor patterning and release approaches to further improve biological response. Here, we discuss the mechanisms of bone repair, the current available technologies, biomaterial design criteria, 3D printing as a fabrication method, and the influence of cells and growth factors on bone repair.

🧪🔬🧬💠 Biomaterial design principles to accelerate #bone tissue #engineering

Dewey & Harley, 2022

doi.org/10.1007/978-...

#biomaterials #biomineralization #collagen #metals #autograft #tissueengineering #regenerativemedicine #implants #bioengineering #science #physics #biology #chemistry