Happy to share some PhD research of @amina-ilyas.bsky.social in @newphyt.bdky.social
We show that the Enterobacter sp. SA187 enhances plant growth under low nitrate by regulating nitrate transporter gene expression and ethylene signaling. #plantscience #beneficialmicrobes

doi.org/10.1111/nph....

Gut Microbes Reshape Mental Health – The Science Matters Could tiny microbes help with stress and anxiety? Learn how psychobiotics influence the gut brain axis and promise hope for mental illness.

TSM Article: Gut Microbes Reshape Mental Health thesciencematters.org/gut-microbes...

#beneficialmicrobes #biotechnologicalpropertiesofprobiotics #gutbrainaxisandprobiotics #gutmicrobiomeandpsychology #probioticsforaging #psychobioticsanddiabeticfootulcers #universityofkarachi

Gut Microbes Reshape Mental Health - The Science Matters Could tiny microbes help with stress and anxiety? Learn how psychobiotics influence the gut brain axis and promise hope for mental illness.

Could tiny microbes help with stress and anxiety? Learn how psychobiotics influence the gut-brain axis and promise hope for mental illness. By @abrarprobiotics.bsky.social, University of Karachi

Article: thesciencematters.org/gut-microbes...

#beneficialmicrobes #gutbrainaxisandprobiotics

Alfalfa (Medicago sativa) inflorescence in crop field. Fallon NV (USA, Aug24)

Hi world! We will use this platform as micro-blogging space to transmit our knowledge about plant-microbe. Next entrance will verse about seed microbiota. Follow us! #plantmicrobeinteractions #beneficialmicrobes #sustainableagriculture #bioinoculants

That's it y'all! Thanks to Kevin Kohl and Katherine Lemon for organizing this year! Congratulations to all the student and postdoc poster and talk awardees! Don't forget to look for the survey if you attended the meeting.
#BeneficialMicrobes

Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology Li et al. identify gut microbes and their metabolic genes that efficiently deplete amino acids. These microbes and their metabolic genes for amino acid utilization affect host amino acid homeostasis. ...

CJ (Chun-Jun) Guo gives the last talk for #BeneficialMicrobes. He develops new tools for human gut microbiota research, looking for collaborators. Asks do bacteria before the host? Answered in this paper, has catalog of 35 metabolism genes altered in gut microbes
www.cell.com/cell-host-mi...

Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic ... bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Izabella Sall studies microbiota in opioid use, points out that prolonged opioid use causes gut microbiota dysbiosis. Butyrate important in opioid tolerance, detected via several methods. See the preprint here: www.biorxiv.org/content/10.1...

#BeneficialMicrobes

Social motility of biofilm-like microcolonies in a gliding bacterium - Nature Communications Bacterial biofilms are aggregates of surface-associated cells embedded in an extracellular polysaccharide (EPS) matrix. Here, the authors describe a unique mode of collective movement by self-propelle...

#BeneficialMicrobes
Shruthi Magesh from the Handlesman lab (which I inferred when I saw Handlesman taking a photo of her student, such a great #ProudPI moment) tells us a fascinating story about multi-species biofilms. Love the name of the communities, zorbs, from: www.nature.com/articles/s41...

Daniel Y. Kim walks us through the potential mechanism of how 502A inhibits growth of MRSA in the nasal environment. I recognize him from a previous meeting and can't place which lab he was in. #BeneficialMicrobes

Multivariable association discovery in population-scale meta-omics studies Author summary Recently, several statistical methods have been proposed to identify phenotypic or environmental associations with features (e.g., taxa, genes, pathways, chemicals, etc.) from molecular...

#BeneficialMicrobes Poole used this for the microbiome analysis: MaAsLin2 (journals.plos.org/ploscompbiol...)

(I love her sense of humor, what a good talk)

Gut microbial features and dietary fiber intake predict gut microbiota response to resistant starch supplementation Resistant starch (RS) consumption can have beneficial effects on metabolic health, but the response, in terms of effects on the gut microbiota and host physiology, varies between individuals. Facto...

Angela Poole studies dietary fiber intake. Recommended dietary intake is MUCH higher than we typically take in. Did a study during the pandemic ( #overlyhonestmethods shared) with high fiber diets, described in this paper: www.tandfonline.com/doi/full/10....

#BeneficialMicrobes

US20240000753A1 - Methods and compositions to increase lifespan and healthspan by mimicking the effects of time-restricted feeding - Google Patents The present disclosure relates to methods and compositions for increasing or extending lifespan and/or healthspan and/or delaying aging using agents which mimic the effects of time-restricted feeding ...

Matthew Ulgherait at UNC studies aging in Drosophila, has identified microbes and feed that can extend the life of the fruitflies. See this patent: patents.google.com/patent/US202...

#BeneficialMicrobes

Johnson makes a very strong case that sphingolipids are important to study because they have big effects distant from the gut. Jokes in the Q&A that the student now has a new project after q from Karen Guillemin. So glad my lab is here for the last session, this should be good.
#BeneficialMicrobes

1-s2.0-S0968000421001845-main.pdf

Johnson lab uses BOSSS to characterize cells that have sphinganine drive.google.com/file/d/1DAZ-...

#BeneficialMicrobes

(see also the P. copri story from her lab on sphigolipids journals.asm.org/doi/full/10....)

Diaper Dashboard

Last day of #BeneficialMicrobes: Liz Johnson from Cornell studies the infant gut microbiome. Some of her data comes from a community project called diaper-project, in which parents donate samples and get a description of their babies microbiome in return.

dashboard.diaper-project.com/signup

Establishing microbiome causality to tackle malnutrition - Nature Microbiology A ‘reverse translation’ strategy using gnotobiotic mice ascertains cause and effect relationships between bacterial members of the gut microbiota, dietary components and host physiology, which are dif...

This summary describes the reverse translation method used to show that P. copri is important for the restoration of the microbiome with MDCF2 #BeneficialMicrobes
www.nature.com/articles/s41...
#BeneficialMicroves

A Microbiota-Directed Food Intervention for Undernourished Children | NEJM More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children ...

Newest work is developing a diet for Bangladesh underdeveloped kids based on microbiota repair. See www.nejm.org/doi/full/10....
#BeneficialMicrobes

He walked us through his Science papers, including Abigail Sayer's describing B theta in 1996, Lora Hooper's about how B theta does EVERYTHING in the gut in 2001, Jian Xu's 2003 paper on the genome of B theta, Sonnenburgs 2005 paper, Ruth Ley's paper on zoom microbiome in 2008. #BeneficialMicrobes

Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system. A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Describes how this paper led him down the journey of gut microbiota research: genesdev.cshlp.org/content/10/8... I am not going to be able to capture all his storytelling, that is a huge bummer

#BeneficialMicrobes

Keynote speaker for the #BeneficialMicrobes meeting is Dr. Jeffery Gordon. My laptop is going to die, so you won't get much from me. He is basically the godfather of microbiome research, including mentoring my PhD PI. Developing Microbiome-directed Therapeutics for Treating Childhood Undernutrition

Marienela Heredia is in the lab of my PI from grad school, Laura Knoll. Heredia studies Entamoeba and Tritrichomonas, which are often thought of as parasites, but have capacity to be symbionts. Love a good parasite/protist story. It's unpublished, looking forward to reading this

#BeneficialMicrobes

Microbiome-derived acidity protects against microbial invasion in Drosophila Barron et al. demonstrate that interactions between members of the Drosophila microbiome influence the pH of the fly environment. Acidification by the microbiome, primarily through production of lacti...

Sneha Agrawal from the Broderick lab focuses on Drosophila microbiome. This work builds off earlier work from Barron et al 2024: www.cell.com/cell-reports...

#BeneficialMicrobes

Andrea Boyd in the Lemon lab has developed a new system to study how nasal microbiome members interact with host cells and it is very cool. Definitely keep an eye out for that publication.
#beneficialMicrobes

Sergio López-Madrigal also studies Wolbachia and is characterizing microbe-host interactions. This work is unpublished as well, but I took notes for a mentee about a potential assay to use in our system.
#beneficialMicrobes

Kali Pruss from the Gordon lab tells an unpublished story, asks not to share on social media. Story is submitted, so keep an eye out.
#BeneficialMicrobes

Identification of Parthenogenesis-Inducing Effector Proteins in Wolbachia Abstract. Bacteria in the genus Wolbachia have evolved numerous strategies to manipulate arthropod sex, including the conversion of would-be male offspring

Laura Fricke in Lindsey lab characterizes the contribution of Wolbachia to embryogenesis in parasitic wasps. I've never thought about microbe contribution to asexual reproduction, will now bug my genetics colleague to look at this in their bug.
academic.oup.com/gbe/article/...
#BeneficialMicrobes

Dominant Bacterial Phyla from the Human Gut Show Widespread Ability To Transform and Conjugate Bile Acids | mSystems Our current knowledge regarding microbial bile acid transformations comes primarily from biochemical studies on a relatively small number of species or from bioinformatic predictions that rely on homo...

Lauren Lucas: bile acids are turned into 100s or 1000s of smaller primary and secondary molecules by microbiota, which play huge role in host health. Lucas is first author on most cited article in mSystems in 2021 (did I hear that right??)
journals.asm.org/doi/full/10....
#BeneficialMicrobes

Transcriptional pathways across colony biofilm models in the symbiont Vibrio fischeri Beneficial microbial symbionts that are horizontally acquired by their animal hosts undergo a lifestyle transition from free-living in the environment to associated with host tissues. In the model sym...

Part of the story that Mandel told us about SypF regulation of Vibrio colonization is in this publication: www.ncbi.nlm.nih.gov/pmc/articles...

#BeneficialMicrobes

#BeneficialMicrobes last afternoon session starts with Mark Mandel walking us through work in squid-Vibrio, with a focus on biofilm formation and Vibrio colonization via phosphorylation signals through rscS and binK. See:

pubmed.ncbi.nlm.nih.gov/26977108/

pubmed.ncbi.nlm.nih.gov/34031036/