Dynamics of genetic circuits in Pseudomonas protegens Genetic circuit engineering enables new cellular functions, yet most circuits are developed in the model host Escherichia coli, limiting their availab…

Latest paper out! This piece was a challenge: logic, predictability, decidability, non-model organisms, design... Kudos to @juanricomol.bsky.social & Pablo Japón #syntheticbiology #synbio #biocomputation (I'll post more on this next week) www.sciencedirect.com/science/arti...

New paper out!📢 Exploring the computing power of microbes that shapes the environment.

In this short review we talk about the "complexity gap", the distance between bottom-up genetic circuits and microbial information processes. Key questions to improve #biocomputation.

🔗 doi.org/10.1016/j.mi...

Side story: NAND gates where one input deals directly with growth control, and it is the actual physical body doing the computation. This is our initial approach to morphological computing in living cells. #biocomputation #alife

Our new strain KT-TTX is truly fascinating. Feedback welcome!

Can design principles be defined for #biocomputation beyond living circuits or standard engineering approaches? Yes. We identified an alternative route based on a class of distributed computation enabling combinatorial design for #synbio link.springer.com/article/10.1...

Huge news for #biocomputation! In a major call (€30M total) for AI proposals, Spain just funded an initiative for implementing AI with living matter using #synbio as the programming tool. The 'AI in vivo project' is a massive, official recognition of biocomputation as a leading field in computing.

Next in Lab's conference agenda: FEMS @femsmicro.org! @vdlorenzo.bsky.social and myself are running a session on bacterial computation. Talks by @yschaerli.bsky.social, @manishmicrobe.bsky.social, Sangram Bagh & organisers. Very looking forward to it! #biocomputation #synbio

Want to know how to handle biological information beyond Boolean logic? What else can we do? Here we suggest stochastic and probabilistic approaches to #biocomputation.

Genetic designs for stochastic and probabilistic biocomputing The programming of computations in living cells is achieved by manipulating information flows within genetic networks. Typically, gene expression is discretized into high and low levels, representing ...

Just published!: "Genetic designs for stochastic and probabilistic biocomputing".

We explore moving beyond binary logic in #SynBio and #Biocomputation using random pulses and p-bits—embracing biological noise to design robust, invertible genetic circuits in cells.

journals.aps.org/pre/abstract...

Why cellular computations challenge our design principles.

We write about computational theory, information, living cells, complexity, computers, evolution... I really enjoyed writing this piece on #biocomputation. Kudos to Lewis & Bruno. www.sciencedirect.com/science/arti...

https://doi.org/10.1093/nar/gkae1256 No description available

Explored phage 🦠 signals + CRISPRi to enable bacterial 🧫 consortia perform complex tasks with coordinated cellular actions 🤝. #BioComputation PMID:39727169, Nucleic Acids Res 2025, @NAR_Open @OTSociety https://doi.org/10.1093/nar/gkae1256 #Medsky #Pharmsky #RNA 🧪

Robot controlled by human 'brain on chip' is a world first: scientists Researchers at Tianjin University in China have created a robot that is controlled by human brain cells in a first-of-its-kind breakthrough in biocomputation.

Researchers have created a #robot that is controlled by human brain cells in a first-of-its-kind breakthrough in #biocomputation that could lead to the development of hybrid human-robot #smart intelligence #Humanoid #IoT #Medicaltech #NewGizmo nypost.com/2024/07/01/t...