🦀🦴Treatment of Cancer-Associated Hypercalcemia

➡️Start with IV fluids
➡️Then hit osteoclasts with #Bisphosphonates or #Denosumab

But remember, real control = treating the malignancy

🔗 www.nejm.org/doi/full/10....

#Hypercalcemia #Malignancy #OncoNephrology #Nephrology #IM #Oncology #MedSky #NephSky

Comparative cardiovascular safety of romosozumab versus bisphosphonates in Japanese patients with osteoporosis: a new-user, active comparator design with instrumental variable analyses Abstract. This study analyzed the association of romosozumab, a human monoclonal antibody with bone-forming and bone resorption-inhibiting effects, and bis

Comparative cardiovascular safety of #romosozumab versus #bisphosphonates in Japanese patients with #osteoporosis: a new-user, active comparator design with instrumental variable analyses
academic.oup.com/jbmr/advance...

Two molecular modelling papers provide fundamental explanation to a recent Harvard observational study.

Some who take #bisphosphonates for #osteoporosis etc. were found to be protected against #covid. We now have a #molecularmodel to explain this. Thanks to my #BITSPilani collaboration.
doi.org/10.1016/j.jm... & tinyurl.com/S27374165235...

@sciencedirect.bsky.social

@harvardchanschool.bsky.social

Effectiveness of Bisphosphonates in Young Adults With Fragility Fractures: Representative Population-based Cohort Study AbstractContext. Fragility fractures in young adults present significant clinical challenges due to the limited evidence on the effectiveness of bisphospho

Effectiveness of #Bisphosphonates in Young Adults With Fragility #Fractures: Representative Population-based Cohort Study
@endosocjournals.bsky.social
academic.oup.com/jcem/advance...

<em>Equine Veterinary Journal</em> | BEVA Journal | Wiley Online Library Background Bisphosphonates are widely used in equine athletes to reduce lameness associated with skeletal disorders. Widespread off-label use has led to concern regarding potential negative effects .....

It’s been too long since I’ve been able to promote my research, so here’s my most favorite recent pub. In short, all that #Tildren (& assuming Osphos, both #bisphosphonates) that we’re giving horses continues to have no effect on the actual bone. #vetmed

In Silico Exploration of Bisphosphonate Scaffolds as Potential Inhibitors of SARS-CoV-2 RdRp for COV... The novel coronavirus disease (COVID-19) pandemic has resulted in over 720 million confirmed cases and 7 million deaths worldwide, with insufficient treatment options. Innumerable efforts are being ma...

www.preprints.org/manuscript/2... We lack safe, effective & cost effective #treatments for #covid. Our latest research into #bisphosphonates has identified three potential #drug candidates (CHEMBL196676, CHEMBL164344, and CHEMBL4291724) that warrant further investigation in cells and animal models.