#Taiwan reports third incidence of #SFTS #tick-borne #disease ...
| #thrombocytopenia | #virus | #bunyavirus | #infections | #publichealth | #Asia | Via taipeitimes .com
Absolutely delighted to share that we’ve been awarded by @wellcometrust.bsky.social with amazing collaborators John Barr, Juan Fontana & Martin Stacey! 🚀 An exciting adventure studying #bunyavirus viral factories with cutting-edge techniques is about to startI! 🔬🧪🦠🧬💻🌟
Culiseta annulata #mosquitoes were recently found for the first time in a glacial valley in Iceland. Iceland was previously one of only two mosquito-free regions globally (the other, Antarctica). Warmer temperatures are expanding the habitat range of this #bunyavirus vector species
bbc.in/47fsy1y
📢 Thrilled to share our NEW PREPRINT!
SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠
🧫 NSs essential for tick but not mammalian infection
🧬 Binds 22-nt viral siRNAs to block RNAi
🕷️ Reveals host-specific viral immune evasion
📖 doi.org/p2vf
#lovevirology #bunyavirus #tickborne
Post 3/5 🧵
DISCOVERY: Virus systematically hijacks tick RNA machinery:
🔹 RNAi pathway: UP (tick defense)
🔹 Translation: UP (viral protein synthesis)
🔹 rRNA processing: DOWN (disrupts cell proteins)
18 proteins both changed activity AND bound viral nucleocapsid!
#bunyavirus
Staining patterns in the villous look like what we previously found with the related #bunyavirus #RVFV.
We have a new pre-print on #Oropouche virus! Recent evidence suggests this emerging #bunyavirus may be associated with #verticaltransmission. Using ex vivo models of the placenta, we found villous trophoblasts are permissive to infection with the #prototype strain BeAn19991.
CCHFV, Pakistan | #bunyavirus @DiagnosticChick @scoopit