DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

This week #JournalClub @labsoap.bsky.social @science.org #cGAS_STING @idikic.bsky.social www.science.org/doi/10.1126/...