FAM151A inhibits hepatitis B virus by modulating cccDNA transcriptional activity

FAM151A emerges as a novel host factor that suppresses #HBV replication by inhibiting #cccDNA transcriptional activity without reducing its abundance, offering fresh insight into #antiviral strategies against persistent HBV infection.
#OpenAccess: doi.org/10.1016/j.ge...

This review provides an overview of #cccDNA biology, describing the various host factors and #ViralProteins regulating its transcription, while discussing novel anti-HBV approaches for eliminating cccDNA transcription.

#OpenAccess: doi.org/10.1016/j.ge...

In a review published in Genes & Diseases on February 3, 2024, a team of researchers delves into the epigenetic regulation of HBV cccDNA.
#cccDNA #Epigenetic regulation
Details: doi.org/10.1016/j.gendis.2024.101215