Evolution tunes functional sub-state interconversion to boost enzyme function Enzymes do not operate as static structures, but continuously fluctuate between different conformations. Enzymes therefore dynamically sample conformations with varying catalytic activity. However, it...

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Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.

#OXA-48 #ceftazidime #enzymeevolution

www.biorxiv.org/content/10.6...

Resistance emerges to newest antibiotic The UK Health Security Agency has found that 6.3% of bacteria tested in routine surveillance showed resistance to ceftazidime/avibactam.

The UK Health Security Agency has found that 6.3% of bacteria tested in routine surveillance showed resistance to ceftazidime/avibactam.

healthcaretoday.com/article/resi...

#healthcare #patientsafety #drugresistance #bacteria #ceftazidime #avibactam

New antibiotic already causing AMR concerns, study results suggest Some bacteria have already become resistant to ceftazidime with avibactam (Zavicefta; Pfizer), one of the newest antibiotics introduced to the NHS, results of a study conducted by researchers at the…

Some bacteria have already become resistant to #ceftazidime with #avibactam (#Zavicefta), one of the newest antibiotics introduced to the NHS, results of a study conducted by researchers at the #UKHSA have revealed

#antimicrobialresistance #AMR
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