We provide evidence that these polyA/T tracts have been repeatedly coopted through #de_novo gene emergence for the evolution of novel small genes encoding proteins ( mostly #microproteins ) with predicted TM domains!

Intergenic polyA/T tracts explain the propensity of yeast de novo genes to encode transmembrane domains Abstract. New genes can emerge de novo from non-genic genomic regions. In budding yeast, computational predictions have shown that intergenic regions harbo

Why do yeast #de_novo genes have so many transmembrane domains? It's because the genomic regions from which they evolved are super enriched in stretches of A's and T's ! Our work with @timothyfuqua.bsky.social is now published in @jevbio.bsky.social
doi.org/10.1093/jeb/...