Pleased to see most recent world, national and university rankings in molecular biology according to research.com @BrownPathology @BrownUniversity @BrownMedicine @BrownUCancer #LegorretaCancerCenter #eldeirylab

Grateful to #eldeirylab for remembering my birthday this week as I was giving a keynote lecture in Cairo on the date last week.

Inhibition of ITGB6 stimulates potent anti-tumor responses in immunocompetent mouse models of head and neck squamous cell carcinoma and pancreatic adenocarcinoma - PubMed <span><i>ITGB6</i>, the gene encoding the β6 subunit of integrin αvβ6, is a potent prognostic marker across multiple cancer types. As a major activator of latent TGFβ and a potent modulator of the tumor immune environment, αvβ6, and consequently, <i>ITGB6</i>, has considerable therapeutic implications. </span> …

Pleased to share PubMed link for the latest publication from #eldeirylab

Inhibition of ITGB6 stimulates potent anti-tumor responses in immunocompetent mouse models of head and neck squamous cell carcinoma and pancreatic adenocarcinoma

pubmed.ncbi.nlm.nih.gov/41523261/

Great to see my @BrownUniversity @BrownMedicine @BrownUnivHealth colleagues Dr. Alex Raufi and Dr. Howard Safran at #GI26 in San Francisco. @bcarneiro7 @ShiOnaCo @rwsobol @LiangChengMD @sendurai @DrSGraff @Roxanne344 #eldeirylab #LegorretaCancerCenter @JerryAzzoli @HinaKhanMD @SheRiseRogersMD

Appreciate presentation by Dr. @Dina_rys about PPAR isoforms beta and delta and breast cancer therapy this morning at the #eldeirylab meeting at #LegorretaCancerCenter

Appreciate presentation by Dr. Verovkina about “Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice” this morning at the #eldeirylab meeting at #LegorretaCancerCenter

Pleased to share paper from #eldeirylab at #LegorretaCancerCenter:

Inhibition of ITGB6 stimulates potent anti-tumor responses in immunocompetent mouse models of head and neck squamous cell carcinoma and pancreatic adenocarcinoma. Am J Cancer Res 2025;15(12):5317-5333.

e-century.us/files/ajcr/1...

Several #eldeirylab members are in lockdown down in different buildings on campus.

Suspect at large after multiple people shot at Brown University The Rhode Island university is telling students to shelter after a shooter was reported near one of its engineering buildings in Providence.

I’m safe and asking #eldeirylab members, colleagues to check in, to follow news and university updates for information and stay safe.

Suspect at large after multiple people shot at Brown University

www.bbc.com/news/live/c3...

Enjoyable #eldeirylab holiday event with traditional gift exchange.
#LegorretaCancerCenter @BrownMedicine

Excellent update by @BrownUPathoGP PhD student @ksmeza at #eldeirylab meeting #LegorretaCancerCenter on some of her ongoing thesis work where she is studying the impact of PIM1 on RCC, the TRAIL pathway, and novel translational therapeutic strategies @SheldonLHolder @amandamjamieson @BrownMedicine

Grateful to Dr. Dinara Ryspayeva for presenting MS on PPAR-delta as a prognostic biomarker and its association with immune infiltrates in breast cancer PPAR-delta as a prognostic biomarker and its association with immune infiltrates in breast cancer at #eldeirylab meeting at #LegorretaCancerCenter

Great to meet new #eldeirylab members including @BrownUniversity undergrad Ben Huang & @BrownMedicine med student @JayRGopal to discuss research directions including in cancer drug development, precision oncology and AI applications. #LegorretaCancerCenter
And view of Danoff LSB.

Great meeting with some #eldeirylab members who recently joined including @BrownMedicine medical student Chris Egg-Krings, & Brown undergraduates Samarth Bedre and Harrison Yu. We discussed their research focused on brain cancers, careers in academic medicine, collaboration & strategies for impact.

Great to spend time with @BrownUniversity Alumni Jeff Waldron, Kenneth Dill and Debi Burke who were also given a tour of some #LegorretaCancerCenter Shared Resources and #eldeirylab during their visit. @LanlanZhou @leiqing_zhang @shengliang15 @LiangChengMD @ShiOnaCo

Happy birthday to #eldeirylab member and MCB Program PhD graduate student Anais Sidonia.
@BrownUCancer @BrownMedicine #LegorretaCancerCenter

Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects TIC10 is a small molecule that activates Foxo3a through dual inactivation of Akt and ERK, up-regulates the expression of the TRAIL gene, an endogenous tumor suppressor, and effectively improves the th...

First report of TRAIL-Inducing Compound #10 (TIC10) discovered in chemical library screen performed in #eldeirylab in 2007 at UPenn👇

Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

www.science.org/doi/10.1126/...

For nearly three decades since my lab reported the discovery of Death Receptor 5, the #eldeirylab has studied the TRAIL pathway that engages a powerful cancer self-destruct apoptosis mechanism through the innate immune system and natural killer cells. youtu.be/5wCkU13SkR4

Welcoming ⁦‪@BrownMedicine‬⁩ medical student Christopher Egg-Krings to the #eldeirylab at #LegorretaCancerCenter ⁦‪@BrownUCancer‬⁩ ⁦‪@BrownUniversity‬⁩ ⁦‪@chriseggkrings‬⁩

Good year for #eldeirylab research, publications, with citations in late September set to match or exceed recent years. #LegorretaCancerCenter @BrownMedicine @BrownUnivHealth @BrownUCancer @BrownPathology

Memory of #eldeirylab group on Nov 11, 2022. Half the group has turned over as careers progressed for the amazing lab members who were with us. 3 went to med schl at U. Arizona, Yale & Columbia. 2 went to residencies at Brown and Cornell. 2 went back to China to medical careers.

Great welcome back to the #eldeirylab for meeting this morning and today I noticed the bridge between the Molecular Medicine building and the new Danoff Life Sciences Building at @BrownMedicine

Great presentation by @connorfpurcell at #eldeirylab meeting this morning of paper addressing molecular mechanisms of prostate cancer neuroendocrine differentiation associated with therapy resistance.

It is so appreciated when an #eldeirylab member takes the time to tidy up the common gel bench as well as their own bench. Collegiality is part of our lab’s culture. It is inspiring to researchers in the environment @BrownMedicine #LegorretaCancerCenter

Proud of our @BrownPathology department for 16% of inventions and #eldeirylab for 8% of inventions at @BrownUniversity over a 3 year period 2023-2025. @BrownMedicine @BrownUCancer #LegorretaCancerCenter @ShiOnaCo @rwsobol @SeanLawler20 @BrownUnivHealth

Nobel Laureate Dr. Kaelin’s comments resonate strongly & were extremely well-articulated. We must remain open for business & keep the chain from breaking. The secret sauce has made us stronger. I can attest the #eldeirylab has always included members from all over the world. youtu.be/Oqgz5Q-KqyU?...

Great presentation this morning at #eldeirylab meeting by @BrownUniversity Pathobiology PhD student Jillian Strandberg on role of CCL22 in radiation pathobiology. Jill previously demonstrated systemic anti-CCL22 therapy has some protective effects towards radiation pneumonitis.

Out on Narragansett Bay with a few #eldeirylab members on a warm July 3rd afternoon.

Congratulations to #eldeirylab, @brownengin PhD student Jillian Strandberg on passing her qualifying exam this afternoon @BrownUniversity @BrownMedicine

Happy birthday to #eldeirylab member and Pathobiology Program PhD graduate student Tyler Roady.
@BrownUPathoGP @BrownUCancer @BrownMedicine