JCI Insight - Dietary Indoles Influence the AHR–RORγt Axis and Mucosal Immune Homeostasis in ART-Treated SIV Infection

Dietary Indoles Influence the AHR–RORγt Axis and Mucosal Immune Homeostasis in ART-Treated SIV Infection

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KRT17 promotes triple negative breast cancer through activation of Wnt signaling and γδ T-cells recruitment - Communications Biology Black American patients with TNBC show elevated KRT17 versus White Americans, linked to poor metastasis free survival. KRT17 activates Wnt signalling, CSCs, and γδ T-cell recruitment, promoting metast...

KRT17 promotes triple negative breast cancer through activation of Wnt signaling and γδ T-cells recruitment

#gdTcells @commsbio.nature.com

Seven subsets, two fates: mouse γδ T cells in cancer immunity The importance of γδ T cells in cancer, as defenders against tumorigenesis, was established more than 2 decades ago. Since that time, research using mouse models of cancer has brought to light a nonun...

Seven subsets, two fates: mouse γδ T cells in cancer immunity: Trends in Immunology www.cell.com/trends/immun...

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ScienceDirect.com | Science, health and medical journals, full text articles and books.

📣We've summarized all there is to know about mouse #gdTcells in cancer and how they relate to humans
@immunowolf.bsky.social #AbhiramMallu #NataliePhinney
check it out here:
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Dual faces of γδ T cells in trypanosomatid infections In this review, we tell the story of how two related parasites that belong to the same genus, Trypanosoma brucei and Trypanosoma cruzi, cause very dis…

Dual faces of γδ T cells in trypanosomatid infections

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In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development Human γδ T cells differ greatly from mouse γδ T cells. La et al. report that it is possible to generate bona fide human γδ T cells in a humanized immune system mouse model. Additionally, they show tha...

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development

#gdTcells @cp-cellreports.bsky.social

Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model In lung cancer, airway macrophages are modulated by an unconventional T cell subset, relevant to care for pulmonary comorbidities.

Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model

#gdTcells @coffeltlab.bsky.social

So great to see this out in print! Congratulations to Yue and @drshrutinaik.bsky.social team on this fantastic story! 🎉 #GDTcells

γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight The success of cancer immunotherapy depends on the mobilization of leukocytes with the capacity to eliminate tumor cells. γδ T cells represent a lymphocyte lineage with strong cytotoxic potential and ...

γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight

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Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection TCRγδ+ intraepithelial lymphocytes (γδIELs) are crucial for maintaining intestinal homeostasis, yet their functional regulation remains incompletely u…

Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection

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Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation

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Frontiers | Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9–associated depletion of gamma delta and mucosal-associated invariant T cells in Lon... IntroductionThe cellular mechanisms underlying Long COVID (LC) associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain poorly unde...

"… revealing widespread transcriptional remodeling across both innate and adaptive immune compartments."

"Mechanistically, we identify Galectin-9–TIM-3 interaction as a potential pathway driving ɣ𝛿 and MAIT cell depletion in LC."

#MECFS #LongCovid #GDTcells

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In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development Human γδ T cells differ greatly from mouse γδ T cells. La et al. report that it is possible to generate bona fide human γδ T cells in a humanized immune system mouse model. Additionally, they show tha...

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development

#gdTcells @cp-cellreports.bsky.social

Unexplored Domain: The Unconventional T Cells in the Male Genitourinary Tract and Related Diseases The immune microenvironment of the male genitourinary tract is orchestrated by immune cells including unconventional T cells, which mainly consist of γδ T cells, natural killer T (NKT) cells, and muc...

Unexplored Domain: The Unconventional T Cells in the Male Genitourinary Tract and Related Diseases

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TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function The human TCRγδ constant region modulates T cell activation and corresponds with T cell clonal expansion and function.

TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function

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Structural biology of γδ T cell receptors T cell receptor (TCR) diversity underpins cellular immunity. While αβ TCRs have been extensively studied in the context of major histocompatibility co…

Structural biology of γδ T cell receptors

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Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy In this opinion article, Silva-Santos et al. discuss the potential of Vδ1+ γδ T cells for cancer immunotherapy, focusing on DOT cells. These in vitro–expan

Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy

#gdTcells @jem.org

Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis - Nature Communications Sex dimorphism in the incidence and mortality of hepatocellular carcinoma (HCC) has been reported. Here the authors show that, in males, androgen promotes regulatory T cell recruitment to impair γδ T ...

Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis

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JCI Insight - Ex vivo expanded allogeneic Vδ2 T cells specifically reduce reservoirs of HIV-1 following latency reversal

Ex vivo expanded allogeneic Vδ2 T cells specifically reduce reservoirs of HIV-1 following latency reversal

#gdTcells @insight.jci.org

Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response.

Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis

#gdTcells @sciimmunology.bsky.social

Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells Author summary Malaria remains one of the deadliest infectious diseases, disproportionately affecting young children in sub-Saharan Africa who succumb to sequelae of Plasmodium falciparum infection. H...

Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells

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Happy Sunday!

ICYMI #GDTcells

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γδ T cell-derived IL-4 initiates CD8+ T cell immunity - Nature Immunology The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.

γδ T cell-derived IL-4 initiates CD8+ T cell immunity

#gdTcells @natimmunol.nature.com

Homeodomain-driven oncogenic diversion to a TCRγδ phenotype in T-cell Acute Lymphoblastic Leukemia Key Points. The vast majority of TCRγδ+ T-ALLs express homeodomain-containing (HD+) oncogenes and display features of pre-αβ cortical thymocytes.Overexpres

Homeodomain-driven oncogenic diversion to a TCRγδ phenotype in T-cell Acute Lymphoblastic Leukemia

#gdTcells @bloodjournals.hematology.org

Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in... While regulatory T cells (Tregs) control autoimmune diseases (AID), the role of evolutionarily older Foxp3+ γδTregs is much less understood. We noted that both lesional and non-lesional skin of patien...

Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in vivo

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Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity Commensals shape host physiology through molecular crosstalk with host receptors. Identifying specific microbial factors that causally influence host …

Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity

#gdTcells @cp-immunity.bsky.social

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma Background Although most studies of anticancer T-cell immunity focus on αβ T cells, γδ T cells are attracting increasing attention due to their involvement in antitumor immune responses in various can...

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma

#gdTcells @sitcancer.bsky.social

Never underestimate the power and the wits of minor immune cell populations.

Come and join us in Wroclaw for next year's #gdTcells #gd2027 conference.

#gd2027 is in Wrocław, Poland. Is this a gd17 🦌vs gdIFN 🦏 matchup? #gdTcells @forum-gd.bsky.social

@lydialynch.bsky.social @neilemccarthy.bsky.social @payalyokota.bsky.social @coffeltlab.bsky.social @ph-papotto.bsky.social @gold-efisch.bsky.social

awesome new review from @edelblumlab.bsky.social about #GDTcells in IBD. Like Karen said, we hope to see many more of you in Wrocław for the #GDT2027 / Poland.

👇