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Structural Features of Glypicans and Their Impact on Wnt Signaling in Cancer

In a recent review paper out of the NIH, Hsi-En Tsao and Mitchell Ho detail the modulatory role of #glypicans in #Wntsignaling & underscore the need for better blueprints of glypican/Wnt/Fzd complexes. Check out their mini review 📝 onlinelibrary.wiley.com/doi/full/10....

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IPI's Deb Moshinsky presented at #SLAS2025 today, outlining our high-throughput SPR testing (using #CarterraLSA), application testing, and cross-reactivity analysis. We’ve applied in our exploration of #neuroscience related #antibodies, including anti- #Glypicans 1-6. Nice work, Deb! 🧑‍🔬

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Ever wonder how signals are passed between growth factors during synapse development? It’s possible #glypicans are involved. Their structure & positioning let them “soak up signaling proteins from outside the cell,” says Adrian Salic @harvardcellbio.bsky.social. Learn more! https://buff.ly/49HFPPK

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