SI-PPC-induced modulation of heparin/heparanase binding affinity: a steered molecular dynamics approach We report a steered molecular dynamics (SMD) investigation into how substitution-inert polynuclear platinum complexes (SI-PPCs) influence the binding affinity between heparan sulphate (HS) and the enz...

📢The authors report a steered molecular dynamics ( #SMD) investigation into how substitution-inert polynuclear platinum complexes ( #SI-PPCs) influence the binding affinity between heparan sulphate ( #HS) and the enzyme #heparanase.

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doi.org/10.1039/D5QI00461F

Design of Paromomycin and Neomycin as Sulfated and Hydrophobic Glycans to Target Heparanase-Driven Tumor Progression and Metastasis Heparanase (HPSE) is the sole mammalian endoglycosidase that degrades heparan sulfate (HS) proteoglycans, disrupting the extracellular matrix (ECM) and promoting cancer invasion and metastasis. Althou...

New research from the Nguyen Lab in the Journal of Medicinal Chemistry explores the therapeutic application of novel inhibitors in attenuating heparanase-driven tumor progression and metastasis, both in vitro and in vivo. #wsuchemistry #heparanase #ChemSky

doi.org/10.1021/acs....

New Approach To Stopping Diabetic Blood Vessel Damage: An enzyme inhibitor drug stops vessel lining damage in the retina, kidneys, and other sites. #diabetes #eye #kidney #endothelial #heparanase #glycocalyx #ubristol
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