Histamine reduced LGN visual responses in awake head-fixed mice. Schematic diagram of LGN recordings (top left) and a representative histological image showing the electrode location (bottom left; DiI stain, red). Right: Schematic diagram of histamine receptor localizations and their cellular function. Chlorphenamine blocks the postsynaptic receptor H1 (orange) that mediates the action of histamine postsynaptically, while ciproxifan blocks the autoreceptor H3 (green) that inhibits presynaptic histamine release.
Internal states & #visual processing: Matteo Tripodi & @hirokiasari.bsky.social show that #histaminergic signaling from #hypothalamus modulates retinal & thalamic responses in mice, so low #histamine during idle periods may speed responses to visual threats @plosbiology.org 🧪 plos.io/49K0Qv8