Redirecting

Latest paper led by Rui Moura, collab with @AnnedesRieux @UCLouvain_be now @JCRnEDITORS. Lipid nanocapsules with retinoic acid significantly reduced disease severity and attenuated demyelination in encephalomyelitis model.
doi.org/10.1016/j.jc...
#MultipleSclerosis #i3SPapers

Redirecting

First paper published in 2026 is out and is a blast! We show that CD44v6-targeted irinotecan nanoparticles + anti-PD-L1 immunotherapy considerably enhance tumor suppression in vivo. Work led by @AnaBaião, now online in @JCRnEDITORS doi.org/10.1016/j.jc...
#i3SPapers #Nanomedicine @CRS_FG_NANO

Rational design of anticancer multidrug nanosystems and their adaptation for glioblastoma treatment - Drug Delivery and Translational Research Multidrug nanosystems emerged as an innovation in anticancer therapy, addressing key limitations of conventional mono- and combination therapies, such as poor tumor selectivity, systemic toxicity, low...

Our latest paper @DDTReMedia explores multidrug nanosystems for hard-to-treat #Glioblastoma, highlighting rational design, simultaneous/sequential delivery, active targeting and stimuli-responsivess. Led by Catarina Pacheco with @uminho.bsky.social
link.springer.com/article/10.1...
#i3SPapers

Redirecting

Using our 3D intestinal inflamed model, we validated a new therapeutic strategy of mesalazine-loaded chitosan/alginate nanoparticles to effectively reduced the pro-inflammatory state. Collaboration with @Unesp now online in @CarbohydratePolymers
doi.org/10.1016/j.ca...
#Genegut #i3Spapers

Modeling the human bladder tissue using three dimensional in vitro approaches as a tool for drug screening platforms The main function of bladder tissue is urine accumulation and excretion, and it is composed of five layers (mucus layer, epithelial layer, lamina prop…

Before taking our first steps toward developing an advanced 3D bladder tumor model (stay tuned!), we carried out an in-depth review to map the state of the art and key challenges and opportunities @ActaBiomaterialia
www.sciencedirect.com/science/arti...

#BladderCancer #3DModels #i3Spapers

Nanocarrier-based intranasal drug delivery for enhanced neurological disorders treatment - Drug Delivery and Translational Research The blood–brain barrier (BBB) represents a major obstacle in the treatment of neurological disorders. While it plays a crucial role in protecting the central nervous system (CNS) from harmful xenobiot...

Particularly proud of this review paper @DDTReMedia by @Cespu pharmacy student Eva Morim, supervised by Catarina Pacheco on how intranasal drug delivery and nanocarrier-based systems can help bypass the BBB for treating neurological disorders.
link.springer.com/article/10.1... #i3SPapers

Take a look on our recent paper at @JCREditors and learn how IBD-specific stimuli can be used to design smarter and more precise nanotherapies. Discover how disease hallmarks can guide drug delivery.
#i3SPapers #nanomedicines #IBD
doi.org/10.1016/j.jc...

#i3Spapers

Investigadores portugueses lutam contra os erros na divisão celular Um estudo liderado por cientistas do i3S, no Porto, abre portas ao desenvolvimento de novas terapêuticas para doenças como o cancro. A investigação assenta num mecanismo que permite corrigir erros na ...

A team of #i3S researchers has uncovered a mechanism that ensures a precise chromosome separation during #celldivision.
Team leader Carlos Conde and researcher Nelson Leça detail the implications of this discovery.
#i3Snews #i3Sresearch #i3Spapers #cancer #cancerresearch

Our latest study on IBD presents an oxidative-responsive #nanomedicine for oral delivery of budesonide. Penetrates mucus, sheds its PEG corona in inflamed colon tissue and releases budesonide at target site. Now online
@JCRnEDITORS
#i3SPapers ‪@crohnscolitisfdn.bsky.social‬
doi.org/10.1016/j.jc...

Redirecting

🚨New strategy against glioblastoma! Targeted nanoparticle for dual delivery of anti-angiogenic + glycolysis inhibitor, via intranasal route🧠
Led by Catarina Pacheco, collaboration with @icvs_uminho
and @SaludISCIII, now online @JCRnEDITORS
@i3suporto.bsky.social #i3SPapers
shre.ink/eky7

Novo mecanismo para corrigir erros associados a cancro descoberto por equipa portuguesa Cientistas identificaram o gatilho para corrigir os erros na divisão celular (que dá origem a novas células). A descoberta detalha o funcionamento do corpo humano e dá pistas para combater o cancro.

A team of #i3S researchers has uncovered a mechanism that ensures a precise chromosome separation during #celldivision.
The finding can pave the way to the development of new therapies to treat faulty cell division-derived conditions, such as #cancer.
#i3Snews #i3Sresearch #i3Spapers #cancerresearch

In collaboration with @uspoficial.bsky.socialwe established a novel sensory neuron-integrated skin spheroid model for screening biological activity in neuronal pathways. Now online at ACS Biomaterials Science & Engineering. @pubs.acs.org #i3SPapers
pubs.acs.org/doi/full/10....

New paper⬇️
#i3Spapers #i3Sresearch

Mesmerizing 😍
#i3Spapers #i3Sresearch

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of <i>M. abscessus</i> Treatments Mycobacterium abscessus (Mab) infections are challenging to treat due to high intrinsic drug resistance, comparable to multidrug-resistant tuberculosis. ...

#i3S researchers Gabriel Oliveira and Tânia Silva feature in a video intro in which they discuss their work and how they carried out the research featured in a paper recently published.
📺👀👇
#i3Sresearch #i3Spapers