IFN-γ–producing TH1 cells and dysfunctional regulatory T cells contribute to the pathogenesis of Sjögren’s disease Treg cell–specific deletion of Ca2+ influx results in a Sjögren’s disease–like phenotype in mice that is mediated by IFN-γ–producing CD4+ T cells.

A new mouse model of #SjogrensSyndrome which develops inflammatory cell infiltrate in #salivaryglands and #lacrimalglands - incredible!

www.science.org/doi/10.1126/...