Sun, Xu & Ye highlight advances in enantioselective γ- #lactam synthesis with chiral α-quaternary centers, one of the toughest challenges in #OrganicSynthesis ! Strategies include asymmetric functionalization of preformed rings & TM-catalyzed carbonylative cyclization⚠️

👉 buff.ly/3tCwIGC

Lifestyle Intervention for Sustained Remission of Metabolic Syndrome This multisite randomized clinical trial evaluates a 6-month habit-based lifestyle program added to education and activity monitoring in patients with metabolic syndrome for sustained remission at 24 ...

Administración de profilaxis antimicrobiana quirúrgica c/no–β-lactámico tiene una probabilidad 1.8 veces mayor de infección en el sitio quirúrgico, por lo que deben evitarse cuando sea posible #prophylaxis #surgical #lactam jamanetwork.com/journals/jam...