#majetilab

Congrats to Thomas & Daiki for this really technically challenging but important study! By correcting the DNMT3A mutation in primary patient samples, they demonstrate that this early mutation is not required for LSC function in vivo.

#majetilab #AML

Interesting, congrats!
#MajetiLab @stanfordmedicine.bsky.social

A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis Ediriwickrema et al. conducted a systematic evaluation of human bone marrow cells and provide an updated model of adult hematopoiesis, which includes distinct, immunophenotypically defined, multipoten...

New #majetilab publication!

Asiri identifies 3 human MPP subsets from adult bone marrow and evaluates their engraftment + differentiation potential. Bonus: a single-cell multi-omics resource.

Check it out here ➡️ bit.ly/4mFSBEa

@stanforddeptmed.bsky.social @cp-cellreports.bsky.social

Featured preprints include our #majetilab collaboration with the Feinberg lab using gene correction of primary samples to reveal that the pre-leukemic mutations in DNMT3A is dispensable for AML disease maintenance.

Read here ➡️ www.biorxiv.org/content/10.1...

@stanforddeptmed.bsky.social