Real-World Avapritinib Therapy Sustains Tolerability Despite Toxicity Rate Avapritinib showed notable grade 3 and higher cytopenias but fewer discontinuations, suggesting manageable toxicity with monitoring.

#Midostaurin had similar severe adverse event rates yet markedly higher discontinuation driven by gastrointestinal intolerance and fatigue. Presented at @theacmg.bsky.social Clinical Genetics Meeting

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#RareDisease #SystemicMastocytosis #MedSky

The approval of #midostaurin for #AML is great news for AML pts! Long journey for PKC inhibitors (I remember staurosporine from my PhD days)