ADCs are Now Listed as a 1L Option in mTNBC - Abi Siva
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#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ADCs #mTNBC
BMI and weight change ≠ survival predictors in mTNBC patients on sacituzumab govitecan. Real-world Polish data show no link to PFS, OS, or AEs.
🔗 Read more: buff.ly/kHtlvYH
#BreastCancer #mTNBC #Oncology
New in JHEOR: High clinical event rates and monthly costs among U.S. patients with metastatic triple-negative breast cancer on chemotherapy underscore need for safer, more effective treatment options. #HEOR #mTNBC #BreastCancer #TripleNegative
Cancer is not cool.
#mTNBC
Innovative Blood Test Offers Hope for Treating Metastatic Triple-Negative Breast Cancer #USA #Creatv_Bio #Monmouth_Junction #LifeTracDx #mTNBC
Do you know anyone with metastatic triple negative breast cancer? Hope is on the horizon with Cytodyn’s Leronlimab.
#mtnbc #cancer #breastcancer
$CYDY. More news coming soon
www.cytodyn.com/newsroom/pre...
New phase III data show Trodelvy plus Keytruda significantly improves progression-free survival in PD-L1+ metastatic TNBC.
Learn more: www.docwirenews.com/post/trodelv...
#BreastCancer #mTNBC #Trodelvy #Keytruda #OncologyResearch
3/👩🏾🦱 Meet Ms Reed
35yo Black woman w #mTNBC
Tumor is PD-L1+ (CPS 10), HER2 low (IHC = 1+)
🚫No known germline BRCA mutation
🖌️Works as graphic designer
On frontline pembro+carbo/gem for 14 wks
2/A good choice for some pts, but not🚫Ms Reed, who is BRCA-negative
🔧 Olaparib & talazoparib=PARP inhibitors
✅ Approved for Tx of germline BRCA-mutated #mTNBC (for olaparib, pts must have rec’d chemo in M0 or M1 setting)
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👇👇👇Try again & pick better tx for Ms Reed👇
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3/📊In ASCENT, PFS benefits w/ SG were seen across clin & demo subgroups
✅NCCN→SG pref'd 2L for #mTNBC (after >2 systemic tx, at least 1 for mets dz)
🆕data suggest G-CSF & loperamide prophylaxis⬇️AEs
👀 Monitor for neutropenia & diarrhea &⬇️dose as needed
🧑🏿🦲Alopecia common AE
6/🗓️Ms Reed 👩🏾🦱 returns 9 wks after starting trastuzumab deruxtecan
She's now received 3️⃣cycles of T-DXd
⏭️She should now have a CT scan & repeat labs
#mTNBC
5/T-DXd binds HER2 on tumor cells
➡️internalized & cleaved by lysosomal enzymes
➡️DxD payload enters cell nucleus
➡️DNA damage & apoptosis
🚧T-DXd also crosses cell membranes
🟰cytotoxic effects on nearby tumor cells, even if they lack HER2 (bystander effect)
#mTNBC
4/💡HER2-low means low but not 0 HER2 expression
🔬Defined as IHC 1+ or IHC 2+/ISH-
~40% TNBCs are HER2-low!
HER2-0 tumors may switch to HER2-low & vice versa at recurrence ➡re-test❗
#mTNBC
2/🫸No!
🛑ing T-DXd & switching therapies when Ms Reed’s #mTNBC is stable would incur unnecessary risk & prematurely use up remaining Tx options🚨
🤝As long as she has stable disease, Tx w/ T-DXd should continue
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👇Select “Continue T-DXd” to move forward👇
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Checking in everyone! How are you doing? I miss you all, I can’t believe a social media app has such an impact on daily life. When you’re having a hard time; we need people who understand. More importantly who can read between the lines and relate. #fckcancer #ThankCancer #MTNBC #family #community
