Initial imaging diffuse tissue edema without gas formation. Emergent surgery is critical for source control, removal of necrotic tissue (which reduces toxin accumulation), and for diagnosis, by obtaining tissue specimens for anaerobic cultures #clostridium #myonecrosis
#clostridium #myonecrosis risk factors: PWID, endometritis in women w/medical abortions w/mifepristone or normal childbirth. C #sordellii-contaminated injection drug➡️extensive deep-tissue infection, cluster of necrotizing fasciitis among black-tar heroin in California
#clostridial #myonecrosis Early antibiotic intervention is essential: penicillin remains drug of choice. Other agents, including metronidazole, clindamycin, and the carbapenems, can also be used for treating clostridial myonecrosis.
most important part of therapy for #clostridial #myonecrosis is emergent surgical debridement of infected tissues.
#clostridial #myonecrosis, medical emergency
Clinical signs such as severe pain at site of injury/surgery, tachycardia in absence of fever/obvious systemic toxicity, +edema, skin discoloration hemorrhagic bullae & gas
Clinically, #clostridial #myonecrosis generally begins within 24 to 72 hours after traumatic injury or surgery. Initial symptoms may include severe pain in the absence of obvious physical findings, suggesting a deep tissue infection.
#Clostridial #myonecrosis, or gas gangrene, is most often caused by a traumatic injury
C #perfringens can be isolated from soil & is also one of most common clostridial species isolated from the intestinal tract of humans and other animals
