Genes for nucleotide synthesis are essential for cell growth, unless nucleosides for salvage are provided. This gave us an idea💡

To identify new players in pyrimidine synthesis, we ran a genome-wide CRISPR-Cas9 screen in media ± uridine, a #pyrimidine #nucleoside.
2/17

Prof. Yitzhak Tor from UC San Diego discussed his research on emissive #nucleoside surrogates, which facilitate real-time monitoring of nucleoside-, #nucleotide- and #nucleic acid-based transformations at nucleobase resolution. He presented examples of their application in biophysical studies.