Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and suppress pathological vasodilation…

New research reveals the molecular mechanism by which a natural molecule, #oxoglutaric acid (α-ketoglutarate) found in some face creams, may help reduce the facial redness seen in #rosacea.

#skin
#inflammation
#science

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