Researchers uncover key players in tissue regeneration The STK38–YAP1 switch may be a general mechanism for mature cells to regain regenerative properties across many organs.

How do tissues regenerate after injury or disease? J. Mills, Y. Zeng et al found new players that mediate the process. @pnas.org @bcmhouston.bsky.social #BCMDeptMedicine #BCMPostDoc #Paligenosis blogs.bcm.edu/2026/04/02/f...

Regulation of STK38 by autophagy governs YAP1 activity during paligenosis | PNAS Paligenosis is a conserved cellular plasticity program that allows mature cells to reenter the cell cycle in response to tissue injury. Paligenosis...

Check out the key new players in tissue #regeneration @pnas.org. J. Mills, Y. Zeng et al @bcmhouston.bsky.social #BCMDeptMedicine #BCMPostDoc #Paligenosis www.pnas.org/doi/10.1073/...

youtu.be/I6M8iuDD0hc?... -- Nice lay video on #paligenosis and #cathartocytosis

Injured Cells Expel Waste to Accelerate Healing, Study Shows

In mouse stomach injury models, researchers identified 'cathartocytosis'—cells rapidly expel internal debris to speed up paligenosis, a finding reported in Cell Reports (2025). getnews.me/injured-cells-expel-wast... #cathartocytosis #paligenosis

Cells ‘vomit’ waste to promote healing, mouse study reveals | Newswise A new study in mice led by researchers at Washington University School of Medicine in St. Louis reveals a previously unknown cellular purging process that may help injured cells revert to a stem cell-...

Cells ‘vomit’ waste to promote healing, mouse study reveals
www.newswise.com/articles/cel...
#stomach #paligenosis #MouseStudy

Yongji Zeng at #DDW2025 in the CMG abstract plenary talking about #Hippo in #paligenosis.

A noncanonical Hippo kinase, STK38, degrades YAP1 at homeostasis.

Autophagy in stage 1 degrades STK38 to activate YAP1 for metaplasia and proliferation (stages 2 and 3).