#Organosodium reagents are emerging as greener, more reactive alternatives to lithium🧪 Benzyl sodium shows divergent reactivity with #pyridines, unlocking access to #dihydropyridines 🔍 New mechanistic insights revealed by Eva Hevia & co-workers @evaheviagroup.bsky.social

👉 buff.ly/DThXVcG

Rapid access to 1,2- #diazepines from #pyridines via ylide formation under 370 nm light, as reported in the paper of Tomislav Rovis & coworkers🚀 Tuning the protecting group enables diverse substrates, offering a one-pot route to rare drug-like cores💊

👉 buff.ly/UXBkq9a

🌟From Cluster Hydrogen Atom Transfer Reactions🌟

S. Hong & co-workers report phosphine-mediated 1,2-HAT of amidyl #radicals via FLP activation – no photocatalyst needed!💡This enables selective C4-alkylation of #pyridines with broad scope⚡

👉 buff.ly/htGLoAw

meta-Selective thiofluoroalkylation of substituted pyridines via Zincke imines Zincke imines enable the regioselective thiofluoroalkylation of substituted pyridines, providing access to thioalkylated pyridines bearing a range of fluorination patterns. Crucial to the success of t...

📢Don't miss this #OCF_research from Omar Boutureira et al.

👉meta-Selective #thiofluoroalkylation of substituted #pyridines via Zincke imines

doi.org/10.1039/D5QO...

Cai and Qin have harnessed pyridine N-oxide #diradicals (via #photoirradiation!) for an 'oxygen walking' strategy, enabling efficient & scalable access to challenging C3-hydroxy #pyridines.
👉 thieme-connect.com/products/ejo...