A hydrophobic core in the coiled-coil domain is essential for NRC #resistosome function

Hung-Yu Wang, et al.

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#PlantScience

Single-cell-resolved calcium and organelle dynamics in resistosome-mediated cell death Plant nucleotide-binding domain leucine-rich repeat-containing (NLR) proteins act as intracellular immune receptors that assemble into resistosomes to execute immune responses. However, the subcellula...

📜 Single-cell-resolved calcium and organelle dynamics in resistosome-mediated cell death

🧑‍🔬 Yi-Feng Chen, Chih-Hang Wu, et al.

📔 @biorxiv-plants.bsky.social

🔗 www.biorxiv.org/content/10.1...

#️⃣ #PlantScience #PlantImmunity #Resistosome

When the α-latrotoxin binds to the receptor of the presynaptic membrane of the signaling cell, it undergoes a transformation: part of the molecule forms a stalk that penetrates the cell membrane ("membrane insertion," right). As a special feature, this stalk forms a small pore in the membrane that acts as a calcium channel. MD simulations revealed that calcium ions (Ca2+ ions) enter the cell through a lateral selective gate directly above the pore. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-52635-5

The poison of the black widow #spider acts like a #resistosome. 😲

#PlantScience meets #Arachnology

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