Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,

Why do disorders caused by chromosomal #aneuploidy, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0

Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,

Why do disorders caused by chromosomal #aneuploidy, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0

Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,

Why do disorders caused by chromosome amplification, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0