Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants Tryptamine psychedelics from plants, fungi, and toads are produced in planta through cross-kingdom pathway reconstruction.

Researchers in #ScienceAdvances have reconstructed the full biosynthetic pathways of five natural psychedelics in one plant system. https://scim.ag/3PLLIFP

Self-regulating hydrogel for diabetic wound healing: From animal models to a pilot clinical study Self-regulating hydrogel controls therapeutic ion release for accelerated diabetic wound healing in clinic trials.

Researchers in #ScienceAdvances have developed a self-regulating hydrogel that enhances diabetic wound healing.

Learn more: scim.ag/47zzh67

Contents | Science Advances 12, 14

With the potential to limit T cell activity locally, a new drug called ImmTAAI may enable targeted immunoregulation treatment for type 1 diabetes.

Learn more in this week’s issue of #ScienceAdvances: scim.ag/3NXU7Wa

Live human pancreas slice with islet cells stained red.

With the potential to limit T cell activity locally, a new drug called ImmTAAI may enable targeted immunoregulation treatment for type 1 diabetes.

Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3NQusPc

Self-regulating hydrogel for diabetic wound healing: From animal models to a pilot clinical study Self-regulating hydrogel controls therapeutic ion release for accelerated diabetic wound healing in clinic trials.

Researchers in #ScienceAdvances have developed a self-regulating hydrogel that enhances diabetic wound healing.

Learn more: https://scim.ag/4m9XyFU

Uncovering simultaneous breakthroughs with a robust measure of disruptiveness An embedding-based disruption measure not only robustly captures disruptive works but also reveals simultaneous discoveries.

The Higgs mechanism was proposed in 1964 by three independent teams.

But here is the puzzle🤔: the "disruption index" says Higgs's paper is among the least disruptive ever.

So what is going on?

In our new paper, just out in #ScienceAdvances, we take up this puzzle: doi.org/10.1126/scia... 👇

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Wheat fiber mitigates colitis via non-SCFA microbial metabolite-trained intestinal macrophages Wheat fiber mitigates colitis by preserving B. thetaiotaomicron, whose metabolites train macrophages to reduce gut inflammation.

According to a new #ScienceAdvances study, wheat fiber-enriched foods may reduce gut inflammation and curb the development of inflammatory bowel disease. https://scim.ag/4uU8z1Q

A galactic cosmic ray cavity in Earth-Moon space Chang’E-4 lunar lander uncovers a cosmic ray shadow sculpted by Earth’s magnetic field.

Data collected by China’s Chang’E-4 Moon lander suggests there is a region of reduced galactic cosmic rays (GCRs) in a sector of the lunar orbit.

This “cavity” is formed by an unexpected extension of the magnetic field produced by Earth. Read more in #ScienceAdvances: https://scim.ag/488Yfcy

El mecanismo es elegante: los exosomas abren reversiblemente las barreras del ojo, depositan un sistema de nanoenzimas directamente en la célula tumoral y la destruyen desde dentro. #Ciencia #CancerInfantil #Nanomedicina #Investigacion #ScienceAdvances #Oncologia #Exosomas

Blood feeding triggers the terminal differentiation of precursor cells in tick salivary glands Blood feeding rewires cell fate in tick salivary glands.

A new #ScienceAdvances study identifies a cellular mechanism that ticks use to feed on their hosts.

This finding may help develop strategies to disrupt tick feeding and pathogen transmission. scim.ag/41zTULP

Contents | Science Advances 12, 13

New research provides insight into succulent development and could be applied in agricultural contexts to engineer water conservation strategies.

Learn more in this week’s issue of #ScienceAdvances: scim.ag/4dEP7A0

Blood feeding triggers the terminal differentiation of precursor cells in tick salivary glands Blood feeding rewires cell fate in tick salivary glands.

We are pleased to share our recent study published in #ScienceAdvances, describing a previously unrecognized cellular mechanism underlying the dynamic gene expression of tick salivary glands during blood feeding. scim.ag/4c8lmGE
#Ticks #VectorBiology #CellBiology #Lyme

Leaves of Kalanchoe thyrsiflora, a member of the Crassulaceae family of succulents also containing Kalanchoë laxiflora.

New research provides insight into succulent development and could be applied in agricultural contexts to engineer water conservation strategies.

Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4bNDGUj

Blood feeding triggers the terminal differentiation of precursor cells in tick salivary glands Blood feeding rewires cell fate in tick salivary glands.

A new #ScienceAdvances study identifies a cellular mechanism that ticks use to feed on their hosts.

This finding may help develop strategies to disrupt tick feeding and pathogen transmission. https://scim.ag/4s295bD

#paper #highlight February 2026

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule

By S. Bielskutė-García et al in #ScienceAdvances

sbe.es/highlights-p...

@xsalvatella1.bsky.social
@irbbarcelona.org
@icreacommunity.bsky.social

Dengue infection elicits skin tissue-resident and circulating CD8+ T cells associated with protection from hospitalization Dengue infection induces marked reshaping of the skin T cell compartment and elicits skin tissue-resident CD8+ T cells.

An analysis of skin and blood after #dengue infection in #ScienceAdvances shows a more dramatic reshaping and enrichment of T cells in the skin, indicating that vaccinations bolstering the skin’s immune response could help protect against dengue infection. https://scim.ag/41ga4Kg

Applying machine learning to identify unrecognized COVID-19 deaths recorded as other causes of death in the United States A machine learning approach suggests that COVID-19 deaths were undercounted unevenly across sociodemographic groups in 2020–2021.

#COVID19 may have caused 155,536 more deaths in the United States between March 2020 and December 2021 than were officially recorded, according to a new #ScienceAdvances study. https://scim.ag/3NpxJ7T

Contents | Science Advances 12, 12

Researchers report the earliest known clay ornamental tradition outside of Europe, offering insights into the social organization of craft production.

Learn more in this week’s issue of #ScienceAdvances: scim.ag/4sgewo8

A butterfly clay bead from Eynan-Mallaha (Upper Jordan Valley), colored red with ochre and marked with fingerprints from a child who modeled it 12,000 years ago.

Researchers report the earliest known clay ornamental tradition outside of Europe, offering insights into the social organization of craft production.

Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3N8v0Qd

A huge thanks to all our colleagues for their feedback and support throughout this journey! 🥂✨

#DevelopmentalBiology #Neuroscience #SpinalCord #StemCells #ScienceAdvances

Ground penetrating radar observations of ancient large-scale deltaic structures in Jezero crater, Mars Ancient deltaic and fluvial structures detected with radar in Jezero crater, Mars hold implications for habitability.

The Perseverance rover has revealed traces of an ancient river system on Mars, detailing another chapter in the watery history of the Red Planet.

Learn more in #ScienceAdvances: https://scim.ag/3PjqKOw

Modeling identities among the first-sedentary communities: Emergence of clay personal ornaments in Epipaleolithic Southwest Asia The discovery of the earliest clay ornaments in Southwest Asia (15,000 years ago) made by children and adults is reported.

Félicitations @laurent-davin.bsky.social pour cet article et la couverture du nouveau numéro de #ScienceAdvances www.science.org/doi/10.1126/...

The Human Organ Atlas The Human Organ Atlas provides open access to 3D images of human anatomy spanning whole organs to cellular scale resolution.

The Human Organ Atlas, a new resource for researchers, clinicians, and educators, is an open-access database of 3D imaging of intact human organs.

The portal includes donor samples with conditions from congenital disorders to COVID-19.

Learn more in #ScienceAdvances: https://scim.ag/4btmhQI

Multiannual environmental forcing shapes breeding phenology and success in a sub-Antarctic seabird A two-year environmental history sets the fate of reproduction in a polar seabird: Insights from an exceptional breeding advance.

New #ScienceAdvances research finds king penguins in the Southern Ocean show a marked resilience to #ClimateChange. https://scim.ag/4sdXFma

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💡How do injured organs know it's time to regrow?
🎯UV-laser microsurgery was used to precisely injure zfish larval fins during live imaging, helping reveal how wound-adjacent cells initiate a tissue-scale Ca²⁺ wavefront & organ-wide repair response.
#Bioimaging #Photomanipulation #ScienceAdvances

Câncer de fígado pode crescer mais devagar com menos proteína na dieta Dieta com baixo teor de proteína mostrou reduzir crescimento de tumores hepáticos em estudo recente

Menos proteína na dieta pode desacelerar o câncer de fígado, aponta estudo liderado por Xinlu Han e publicado na Science Advances. 🧬
Leia: falaciencia.com.br/cancer-de-fi...

#ciencia #cancerdefigado #saude #pesquisa #ScienceAdvances

Chimpanzees are not more aggressive than bonobos but target sexes differently Chimpanzees and bonobos differ in aggression distribution but not magnitude.

Bonobos bully as much as chimpanzees—but their victims differ by sex, according to new #ScienceAdvances research. scim.ag/40YdJw7

Contents | Science Advances 12, 11

A new study shows that trained dogs exploit indecisiveness to herd sheep and divide the flock.

Based on this, the authors developed an Indecisive Swarm Algorithm that can more efficiently control time-varying networks. Learn more in #ScienceAdvances: scim.ag/40n4e9J

A new study shows that trained dogs exploit indecisiveness to herd sheep and divide the flock.

Based on this, the authors developed an Indecisive Swarm Algorithm that can more efficiently control time-varying networks. Learn more in #ScienceAdvances: https://scim.ag/4boe8Nm

Original post on fediscience.org

Another study showing that interacting with #biased #AI assistants can change one's views, even when people are aware of interacting with a biased algorithm.

#ScienceAdvances
#OpenAccess

Biased AI writing assistants shift users’ attitudes on #societal issues […]