I’m happy to announce that our preprint is out! 🧬🐭

We show that the mouse HSR selfish DNA kills embryos that do not inherit it through a toxin–antidote system, thereby increasing its transmission to the next generation. ⚡

Feedback is welcome!

@takashiakeralab.bsky.social

#SelfishDNA #meiosis4eva

Drive, suppression, and escape from suppression of a selfish chromosome
Bladen, J., Phadnis, N. et al.
Paper
Details
#SelfishDNA #ChromosomalSuppression #GeneticResearch

Join our #MEEGene #seminar at @leibnizlib.bsky.social on zoom tomorrow, July 1, 3PM CEST (Berlin) and listen to Duilio Silva from the NIH, National Heart, Lung, and Blood Institute, USA talking about " #Evolution of a mouse #selfishDNA"
Email meegene@leibniz-lib.de for login details.

I couldn't find a single informative figure to illustrate the RIP mechanism in silencing transposons. Anybody have one? #Transposons #TransposableElements #TEs

RIP recognizes duplicated DNA regions, &, if length & sequence identify pass a certain threshold, it "kills" these duplicated genetic elements by inducing point mutations.

This system works great to inactivate and control #TEs (or #SelfishDNA content) in the genome-> A Transposon-Killing mechanism!