📖✨Congratulations to Dr. Michael Fehlings, Senior Scientist at UHN’s Krembil Brain Institute, for his recent publication in Global Spine Journal!

🔗: linktr.ee/krembil

#SpinalCordResearch #DegenerativeCervicalMyelopathy #DCM #NoResearchNoCure

Angiogenesis-associated neurons in the compressed cord. Representative micrograph of axial sections derived from WT mice and Enpp1flox/flox/EIIa-Cre. (A, B) Double immunohistochemistry with anti-Vegf (green) and anti-Neun (red) antibodies revealed Vegf-positive neurons in the Enpp1flox/flox/EIIa-Cre mice spinal cord sections in contrast with normal spinal cord sections on white matter and gray matter. (E, F) Double immunohistochemistry with anti-Vwf (green) and anti-Neun (red) antibodies revealed Vwf-positive neurons in the Enpp1flox/flox/EIIa-Cre mice spinal cord sections in contrast with normal spinal cord sections on white matter and gray matter. (C, D, G, H) Chronic progressive compression of the cervical spinal cord significantly decreased neuroangiogenesis, as measured by unbiased cells/fields of view. (I) Relative Vegfa, Vwf, Mmp9, Mmp2, and Pecam1 expression, as assessed by RT-qPCR. (J) Analysis of Vegf protein expression levels. Data are expressed as mean ± SD. *p < 0.05, **p 

Recent work by Zhongyuan He & coauthors unveils a validated mouse model of chronic spinal cord compression, mimicking ossification of the posterior longitudinal ligament in humans: onlinelibrary.wiley.... #SpinalCordResearch #OPLL #MouseModel

Decoding the spatiotemporal regulation of transcription factors during human spinal cord development - Cell Research Cell Research - Decoding the spatiotemporal regulation of transcription factors during human spinal cord development

Unveiling human spinal cord development, a novel method reveals intricate spatiotemporal regulation of transcription factors vital for sensory and motor functions. #transcriptionfactors #spinalcordresearch PMID:38177242, Cell Res 2024

New Discovery Could Help Fine-Tune Scarring in Spinal Cord Injuries Summary: UCSF researchers have uncovered a molecular pathway that controls scar tissue formation after spinal cord injuries, potentially paving the way

UCSF scientists unveil key to controlling scar tissue in spinal cord injuries. Fascinating stuff! #SpinalCordResearch #MedicalBreakthrough @UCSF @UCSFMedicine #sciencenews scienceblog.com/547859/new-d...