New work out the lab:
Modeling the effects of #Huntington's disease on age-related genes reveals CXXC4 as an #epigenetic target to restore health and excitability of Drd1-expressing #striatal neurons
Preprint: lnkd.in/ejUpk5ak
#Neuron #aging #rejuvenation #CNRS #innovation #EHDN #systemsmodeling
Top: Schematic of the behavioral regimes followed by ex vivo electrophysiology. Bottom left: Experimental configuration in horizontal brain slices containing the DLS. Bottom middle: The post-pre pairing protocol (negative STDP) for the induction of t-LTD. Bottom right: Confocal laser scanning microscopy images of triple immunofluorescence for adenosine A2A receptor (A2AR), substance P (SP), and biotin in patch-recorded neurons (scale bar: 20 µm).
Instrumental actions rely on flexible, goal-directed #behavior, but can become more rigid & habit-like with repetition. @vincentpb.bsky.social &co show that decreased adaptive signaling capacity of #striatal mGluR1/5 is key to this loss of #BehavioralFlexibility @plosbiology.org 🧪 plos.io/3JaRLAk
Top: Schematic of the behavioral regimes followed by ex vivo electrophysiology. Bottom left: Experimental configuration in horizontal brain slices containing the DLS. Bottom middle: The post-pre pairing protocol (negative STDP) for the induction of t-LTD. Bottom right: Confocal laser scanning microscopy images of triple immunofluorescence for adenosine A2A receptor (A2AR), substance P (SP), and biotin in patch-recorded neurons (scale bar: 20 µm).
Instrumental actions rely on flexible, goal-directed #behavior, but can become more rigid & habit-like with repetition. @vincentpb.bsky.social &co show that decreased adaptive signaling capacity of #striatal mGluR1/5 is key to this loss of #BehavioralFlexibility @plosbiology.org 🧪 plos.io/3JaRLAk
