📢 Part of our group will go to @gcb-bioinformatics.bsky.social next week! Join us at our posters to learn & discuss about:
🧬methylation biomarker detection in cancer research (P032)
🔧the tool sugar (P036) and it's application for identifying micro #synteny (P073)
🦠our virus database #VirJenDB (P109)

To answer these questions and explain the counterintuitive conserved expression of divergent genes, here we have performed #phylogenetic and #synteny analyses of FoxQ2 #genes from 21 animal phyla. 🧬

To answer these questions and explain the counterintuitive conserved expression of divergent genes, here we have performed #phylogenetic and #synteny analyses of FoxQ2 genes from 21 animal phyla. 🧬

Unbiased anchors for reliable genome-wide synteny detection | Algorithms for Molecular Biology | Full Text Orthology inference lies at the foundation of comparative genomics research. The correct identification of loci which descended from a common ancestral sequence is not only complicated by sequence divergence but also duplication and other genome rearrangements. The conservation of gene order, i.e. synteny, is used in conjunction with sequence similarity as an additional factor for orthology determination. Current approaches, however, rely on genome annotations and are therefore limited. Here we present an annotation-free approach and compare it to synteny analysis with annotations. We find that our approach works better in closely related genomes whereas there is a better performance with annotations for more distantly related genomes. Overall, the presented algorithm offers a useful alternative to annotation-based methods and can outperform them in many cases.

Unbiased anchors for reliable genome-wide #synteny detection almob.biomedcentral.com/articles/10....