#thioesterase

Nanobody-thioesterase chimeras to specifically target protein palmitoylation - Nature Communications Reversible palmitoylation regulates the activity and localisation of numerous proteins. Here, Kuo et al develop nanobody-based reagents to specifically target palmitoylation of individual proteins, us...

Soooo excited to share this, just published. www.nature.com/articles/s41.... It started as a crazy ‘Friday afternoon’ experiment and just… worked. And kept on working. We fused a #nanobody to a #thioesterase. This delivers the thioesterase to a target and specifically depalmitoylates this protein