Thank you @mskcancercenter.bsky.social for highlighting our work on #viralmimicry in our genome, its evolution, the selective forces on it, and its potential role in cancer.

A great years long collaborative effort with @petrsulc.bsky.social, @daniel-decarvalho.bsky.social, & many great colleagues!

Check out our review on the role of #retroelements and #viralmimicry during cancer treatment! @neoviral.bsky.social

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

👉 buff.ly/ikXlqbh

#ViralMimicry #Inflammation #HGSOC #Retroelements

We were able to quantify lots of interesting events, such as the rate LINE-1 inserts inverted copies, important for the generation of #viralmimicry through creation of "non-self" double-stranded RNA in the self genome.

We recently explored this phenomena in cancer below:

cell.com/immunity/pdf/S

Now online in Cancer Discovery: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion - by @cishak.bsky.social, Sajid Marhon, @daniel-decarvalho.bsky.social, and colleagues @pmresearch-uhn.bsky.social @mdanderson.bsky.social doi.org/10.1158/2159...