Dominant RDH12-retinitis pigmentosa impairs photoreceptor development and cone function in retinal organoids Retinal dehydrogenase 12 (RDH12) is a photoreceptor NADPH-dependent retinal reductase enzyme, converting all- trans -retinal to all- trans -retinol. Heterozygous variants in RDH12 cause a rare autosom...

Moosajee Lab developed the first model for RDH12-autosomal dominant retinitis pigmentosa using #retinalorganoids and showed shorter photoreceptor segments and fewer photoreceptors as compared to controls.

#visionreseach

www.biorxiv.org/content/10.1...