The Risk of GLP-1 Receptor Agonist (GLP-1 RA) Exposure in Early Pregnancy. A Call to Action: Quantifying the Impact on Pregnancy Outcomes in the United Kingdom - PubMed The Risk of GLP-1 Receptor Agonist (GLP-1 RA) Exposure in Early Pregnancy. A Call to Action: Quantifying the Impact on Pregnancy Outcomes in the United Kingdom

Incretin/GLP-1 users include many women of childbearing age. We discuss if this can have consequences for pregnancy outcomes.

@ncaresearchnhs.bsky.social

pubmed.ncbi.nlm.nih.gov/42017293/

Hyperplasie thymique chez un adulte atteint de la maladie de Graves [Voir la version anglaise de l’article ici : www.cmaj.ca/lookup/doi/10.1503/cmaj.250929][1] Un homme âgé de 47 ans présentant un inconfort à la partie supérieure du thorax, de la difficulté à avaler ...

Now re-published in the French language edition JAMC
www.cmaj.ca/content/198/...

Acromegaly | NEJM To the Editor: In their review article, Giustina and Colao (November 13 issue)1 discuss acromegaly and its craniofacial manifestations. Dentists and oral and maxillofacial surgeons are often among ...

Acromegaly | New England Journal of Medicine www.nejm.org/doi/full/10....

@safwaanadam.bsky.social and Syed.
We propose a role for incretin therapies in the management of coexisting conditions such as obesity, obstructive sleep apnea, and diabetes..
@ncaresearchnhs.bsky.social
@manchester.ac.uk

In The #Endocrinologist, @safwaanadam.bsky.social and @akheelsyed.bsky.social, describe the various biological effects of obesity in worsening the health of the heart muscle and blood vessels, and how weight loss treatments have benefits for cardiovascular health too. 🫀

Read more👉 shorturl.at/KML5v

Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Request PDF Request PDF | Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Hyperthyroidism adversely affects quality of life (QoL), encompassing physical, mental ...

Thyroid overactivity worsens patients' quality of life (QoL). After treatment, QoL is not completely restored for many patients. We discuss reasons, and new approaches to address long-term effects on QoL.
@ncaresearchnhs.bsky.social
@endoconnect.bsky.social

www.researchgate.net/publication/...

A young woman with Kallmann syndrome and acute neurologic symptoms Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.

What's the diagnosis? Be warned: Not everything is as it seems!
Ali, @adhithyasankar.bsky.social, et al. @ncaresearchnhs.bsky.social

www.ccjm.org/content/93/1...

Women under 45 are at increased risk of vitamin D and calcium deficiencies after bariatric surgery.
@ncaresearchnhs.bsky.social

rdcu.be/eYuiy

Accompanying commentary by Nagayama and Yamashita in Thyroid. www.liebertpub.com/doi/10.1177/...

Weight Gain after Treatment of Hyperthyroidism is Associated with Impairment of Quality of Life - PubMed <span><b><i>Background:</i></b> There is evidence of quality of life (QoL) impairment and weight gain in treated hyperthyroidism. It is not known whether treatment-related weight gain is associated with QoL impairment in this patient group of this cohort. Our primary aim was to examine whether percentage</span> …

Weight gain after treatment of hyperthyroidism is associated with a large adverse effect on quality of life.
Angelos Kyriacou et al.
@ncaresearchnhs.bsky.social
pubmed.ncbi.nlm.nih.gov/41448910/

Recognising obesity as a primary driver of CVD reinforces the need for early, proactive intervention.
@safwaanadam.bsky.social
@socendocrinology.bsky.social
@ncaresearchnhs.bsky.social
www.endocrinology.org/endocrinolog...

Thymic hyperplasia in an adult with Graves disease A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...

Thymic hyperplasia:
Thymic hyperplasia, common in children and adolescents, is unusual in adults owing to age-related involution.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250929

Thymic hyperplasia in an adult with Graves disease A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...

Jack Roddy, Shaishav Dhage and Akheel Syed.
@ncaresearchnhs.bsky.social
Treat the Graves' hyperthyroidism and the thymic hyperplasia resolves.

www.cmaj.ca/content/197/...

Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis Long-term outcomes of Roux-en-Y gastric bypass (RYGB) in adolescents are limited. This systematic review and meta-analysis evaluates the safety and efficacy of RYGB in adolescents with obesity. A comp...

Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis - Surgery for Obesity and Related Diseases www.soard.org/article/S155...

Adult Adrenal Insufficiency To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone

jamanetwork.com/journals/jam...

Adult Adrenal Insufficiency To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam...
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults

Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis - International Journal of Obesity International Journal of Obesity - Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis

More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose
nature.com/articles/s41...

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | NEJM Orforglipron, a small-molecule, nonpeptide oral glucagon-like peptide-1 (GLP-1) receptor agonist, is being investigated as a treatment for obesity. In this phase 3, multinational, randomized, doubl...

Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss
www.nejm.org/doi/full/10....

Is that true? Actually, I don't want to know!

Obesity and Metabolic Syndrome: Current Insights and Future Directions | British Journal of Hospital Medicine Obesity and metabolic syndrome are global health challenges, significantly increasing risks for type 2 diabetes, cardiovascular and cerebrovascular diseases, and overall mortality. This narrative revi...

Obesity and Metabolic Syndrome: Current Insights and Future Directions. Zaiem Zarkasi, Rajshekhar N. Mudaliar, Waseem A. Majeed, and Akheel A. Syed.
British Journal of Hospital Medicine
www.magonlinelibrary.com/doi/full/10....

Semaglutide: FDA approves weight loss jab to treat severe liver disease The US Food and Drug Administration has approved the weight loss drug semaglutide, marketed as Wegovy, for the treatment of patients with a severe form of liver disease called metabolic associated ste...

“With only one other drug, resmetirom, specifically approved for the treatment of MASH, the new approval of semaglutide, a drug from a well known and widely used class of medications for type 2 diabetes and obesity, is most welcome.”
www.bmj.com/content/390/...

Type 2 diabetes: SGLT-2 inhibitors to be offered as first line treatment in major guidance “shake-up” Doctors could soon be offering sodium-glucose cotransporter-2 (SGLT-2) inhibitors as a first line treatment option for all patients with diabetes, not just those with heart disease.1 The change has b...

Type 2 diabetes: SGLT-2 inhibitors to be offered as first line treatment in major guidance “shake-up”
www.bmj.com/content/390/...

Use of incretin-based therapies in women using hormone replacement therapy (HRT) - PubMed Use of incretin-based therapies in women using hormone replacement therapy (HRT)

Incretin-based therapies delay gastric emptying and therefore may reduce the absorption of any oral component of HRT. @annicemukherjeemd.bsky.social et al.

pubmed.ncbi.nlm.nih.gov/40378270/

Severity of thyrotoxicosis is a risk factor for excessive weight gain in treated hyperthyroidism - PubMed More than half the patients with hyperthyroidism had ≥10% PWG post-treatment. Indicators of disease severity, namely disease-related weight loss and baseline thyroid hormones, were predictive of exces...

In this study, more than half the patients with hyperthyroidism had ≥10% peak weight gain after treatment. We need to acknowledge, recognise and manage this issue better.
pubmed.ncbi.nlm.nih.gov/40238086/

NEW BMS Tool for Clinicians – Use of incretin-based therapies in women using HRT NEW BMS Tool for Clinicians – Use of incretin-based therapies in women using HRT

annicemukherjeemd.bsky.social et al discuss considerations when prescribing incretin-based therapies in women using HRT during the menopause transition and postmenopause; and
thebms.org.uk/2025/04/new-...

Training refugee and asylum seeking healthcare professionals: an ethical approach to UK workforce challenges Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals Wars in Gaza, Lebanon, Sudan, Syria, Ukr...

Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals @bmj.com

www.bmj.com/content/388/...

Querying stool for dietary information - Nature Metabolism Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic...

A new way to measure your food intake, from your 💩
www.nature.com/articles/s42...
www.nature.com/articles/s42...
"proof-of-concept for detailed tracking of
individual-specific, health-relevant dietary patterns without the need for questionnaires."

Thanks for sharing 🙏🏻
This review is open access and aimed at all health professionals involved in menopause care

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing p...

Very comprehensive review by two top experts in the field.

onlinelibrary.wiley.com/doi/10.1111/...

Good, educational case report 👍
As low-grade TPOAb positivity is not uncommon in the background population, was it an innocent bystander with no predictive value for TED? Or a marker of general autoimmune tendency thereby indicating risk for de novo TRAb production?

Obesity Management for Patients with Coronary Artery Disease and Heart Failure

Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery.
@ncaresearchnhs.bsky.social

www.sciencedirect.com/science/arti...