Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Next-gen imaging technologies enable us to see cells & tissues in extraordinary detail, powering discoveries in cancer, infection & more.

See how talent & tech combine to accelerate research: www.wehi.edu.au/news/seeing-...

#BiomedicalResearch #AdvancedImaging

New paper in Genes & Dev: we dissected how Sox2 — a key pluripotency TF — is regulated by a distal enhancer cluster (SCR) 100 kb away. The results challenge simple models of cohesin-mediated loop extrusion of gene regulation. genesdev.cshlp.org/content/earl... 🧵

On behalf of Tim Johanson and myself (and also previously Christine Keenan)we are indebted to all the speakers and members of the community over the last 5 years. Thank you for your generosity! It has been a pleasure and we look forward to watching GOA develop under Hannah and Zoe’s leadership!

I am excited about the first GOA seminar for 2026. GOA is now in the more than capable hands of @hannah-coughlan.bsky.social and Zoe Grant @gladstoneinst.bsky.social

Please join us for the next edition of the GOA monthly seminar series A/Prof. R. Babak Faryabi @faryabi.bsky.social!

Registration link: unimelb.zoom.us/webinar/regi...

Just a quick reminder that the first of these Associate Professorships have a closing date for applications of April the 8th. Get your application in now!
Please repost

Three researchers posing for portraits

WEHI researchers Prof Alan Cowman AC, Dr Belinda Phipson and Prof Sant-Rayn Pasricha have each received esteemed awards from the Australian Academy of Science, recognising their outstanding contributions to science.

More: www.wehi.edu.au/news/from-ma...

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

It’s well known that inflammation increases cancer risk, but how?

The answer: the epigenome "remembers" inflammation and primes stem cells for cancer.

Here is our paper: nature.com/articles/s41...
And a special shoutout to the lead author
@snaga13.bsky.social

A 🧵

Researchers standing in front of whiteboard with scientific information

WEHI researchers have led a major global effort to create the first authoritative atlas for E3 ligases, resolving more than 18 years of inconsistencies in the ubiquitin field.

Study led by Dr Ngee Kiat ‘Jake’ Chua & Dr Rebecca Feltham in @cellpress.bsky.social

www.wehi.edu.au/news/new-enz...

Delighted to share the lab's latest led by superstar Janith and funded by @snowmedical.bsky.social.
What happens when embryonic factors are reawakened in cancers? We uncovered how DPPA2/4 amplify chromatin states in non-small cell lung cancer 🧬🔬🧪
genesdev.cshlp.org/content/earl...
Tutorial 👇 (1/8)

𝗢𝘂𝘁 𝘁𝗼𝗱𝗮𝘆: Research at Peter Mac led by @meleckmas.bsky.social has uncovered a surprising driver behind aggressive lung cancer — embryonic proteins that are normally only active before birth.

Read more: www.petermac.org/about-us/new...

#LungCancerResearch #LungCancer

Just out! 👀 for TFs that regulate TEs.Clara's work with @tamas-schauer.bsky.social @marliesoomen.bsky.social @palmrinmoy.bsky.social and bluesky-less lab members 🌎 identifies TBP as a regulator of specific ERVL class: MaLRs in 🐭embryos -as always -feedback welcome👍

link.springer.com/article/10.1...

🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...

Electrostatic properties of disordered regions control transcription factor search and pioneer activity - Nature Communications This work describes how positive charge in the peptide chain flanking the DNA-binding domain of transcription factors speeds up their search on free and chromatinized DNA, helping to explain why some ...

How do electrostatic forces impact TF search ? In joint effort with @beatfierz.bsky.social , tour-de-force from @simsakong.bsky.social who single-handedly combined in vitro SPT on DNA & chromatin, in cellulo SPT, ChIP-seq and ATAC-seq www.nature.com/articles/s41...

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Don't forget to sign up - outstanding speakers, great discussions - join us in Munich in *July* 👇👇👇👇👇👇👇

🌱 🚨Postdoc position – Plant Chromatin Biology (Strasbourg)
Grob and Jullien Lab - details attached
📅 Apply by March 30, 2026
📩 stefan.grob@cnrs.fr
Please share with anyone who might be interested!
#Postdoc #PlantScience #Epigenetics #Chromatin

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize...

1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. www.cell.com/molecular-ce...

If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️
We are looking for a postdoc to join our team at @imbavienna.bsky.social
More details 👇🏻

Finally, today's offering! www.biorxiv.org/content/10.6...

This began life as a very different project which failed because we couldn't agree on defining eqtl sharing across cohorts. So two young members of the lab dug deeply into this - first @ijbeasley.bsky.social, then @patrickgibbs.bsky.social

Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar.
Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse.
www.biorxiv.org/content/10.6...

Decoding the molecular logic of rapidly evolving ZAD zinc finger proteins in Drosophila Identification of ZAD-ZnF genes as key regulators of genome organization during Drosophila embryogenesis.

Diving into evolutionary biology! What is the origin of the most abundant class of insect transcription factors, ZAD-ZnFs? We suggest that they evolved from ancestral insulator-binding proteins that control 3D genome topology.

www.science.org/doi/10.1126/...

New pre-print identifying 29 Covid GWAS variants that drive allele-specific activity in a functional genomics screen in lung cells, from @gweykopf.bsky.social and
@eliasfriman.bsky.social @simonbiddie.bsky.social

www.biorxiv.org/content/10.6...

@uoe-igc.bsky.social
@uk-fgx.bsky.social

We wrote a piece on how easy it is to write gene regulatory sequences. - Turns out, it isn't that easy even though we know a lot about cis-regulation.

huge credit to @carldeboer.bsky.social to seeing this through so our thoughts aren't lost. I promise, it's a worthwhile read!

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🚨 We’re happy to announce (finally!) the publication of METALoci, in collaboration with @dariloops.bsky.social and heroes: @jrotwitguez.bsky.social & @imotagom.bsky.social.

METALoci integrates #3DGenome and #Epigenetics data into a unified framework we believe is very useful!

Here 👉🏻 rdcu.be/e5sm2

Fellowship application dealdine for students from low income countries 🌐will be in 1️⃣ week.
Dont miss out on this opportunity ! Hands on Summer School.
Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➡️Unique opportunity ! 15 exiting days ➕ Daily high profile lectures.
👉 bit.ly/4oGDR8f

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - Nature Biotechnology Trimodal single-cell analysis reveals gene-regulatory architecture in complex tissues.

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - @yaruidiao.bsky.social @dukehealth.bsky.social go.nature.com/4rZqimf

Review: @stjude.bsky.social @cp-molcell.bsky.social
Density transitions in the regulation of transcription
www.cell.com/molecular-ce...