TECHNOLOGY: Job Dekker from @umasschan.bsky.social  and Howard Hughes Medical Institute explored the mitotic inheritance of chromosome folding programs at the 2026 AGBT General Meeting.

#AGBTGM26 #Genomics #3DGenome

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🚨 Happy to see that my PhD work is finally published!

We present METALoci, a tool that integrates #3Dgenome and #Epigenetics to identify regulatory hubs.

Applied to #sexdetermination we uncover:
✔️ Non-coding regulatory region controlling Fgf9
✔️ Meis genes as key players

👉 rdcu.be/e5sm2

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs - Nature Structural & Molecular Biology METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors ...

🔊💥 How is sex determined? How is it encoded in the #3Dgenome?

Read all about it in our last paper!
www.nature.com/articles/s41...

It’s been looong but feels satisfying to see this finally out.

(With CapelLab, @dariloops.bsky.social Lab and @mamartirenom.bsky.social Lab)

🧵👇

7/n Here, we applied METALoci, an approach that integrates #3DGenome and #Epigenetics data into a unified framework maps, developed by @jrotwitguez.bsky.social & @mamartirenom.bsky.social from @cnag-eu.bsky.social @crg.eu

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🤩💪 Out now! 3D regulatory hubs in sex determination

With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social

1️⃣ METALoci – explore #3DGenome 🧬
2️⃣ Non-coding region controlling Fgf9 🧩
3️⃣ Meis genes = new key players 🌟

👉 rdcu.be/e5sm2

1/n Bluetorial 👇

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🚨 We’re happy to announce (finally!) the publication of METALoci, in collaboration with @dariloops.bsky.social and heroes: @jrotwitguez.bsky.social & @imotagom.bsky.social.

METALoci integrates #3DGenome and #Epigenetics data into a unified framework we believe is very useful!

Here 👉🏻 rdcu.be/e5sm2

2️⃣ 𝘛𝘩𝘦 𝘧𝘪𝘳𝘴𝘵 𝘴𝘵𝘦𝘱
To provide new answers to these questions, researchers began by obtaining the tiny gonadal cell populations before and after sex determination. Surprisingly, even using Hi-C and ChIP-seq, only minimal 3D chromatin changes were observed

#3DGenome #Nature #Research #HiC #ChIPSeq

📺 Now on YouTube: @dariloops.bsky.social on the evolution of 3D chromatin organization across metazoan species.

Part of our "The 3D Regulatory Genome" seminar series 🧬

🔗 www.youtube.com/watch?v=WoPA...

#Genomics #3DGenome #Epigenetics #Evolution

Michal Gdula group leader at @uam-ibmib.bsky.social is saerching for a postdoc to work on the epigenetics of pancreatic cancer within colaborative OPUS-LAP funded by @ncn.gov.pl and @dfg.de - reach out! #3Dgenome #cancer #pancreas

🧬 Next seminar: @dariloops.bsky.social on how 3D chromatin organisation evolved across species—from CTCF-driven vertebrate TADs to chromatin-based invertebrate domains.

THURSDAY 12 FEBRUARY | 4PM UK | Zoom

Register: us02web.zoom.us/webinar/regi...

#Genomics #3DGenome #Evolution

#Multiomics reveal nuclear #PKM2 drives #PCOS via histone lactylation and #3Dgenome remodeling; inhibition of PKM2 nuclear accumulation alleviates PCOS‑like traits, positioning PKM2 as a promising therapeutic target. #medsky

#STTT: doi.org/10.1038/s413...

Job offer 2026.pdf

🧬 We’re #Hiring a #Bioinformatician/ Computational Biologist!
#Single-cell genomics, #Epigenomics & #3Dgenome biology in #Zebrafish #DevBio 🐟
📍 @cabd-upo-csic.bsky.social, CABD, Seville (Spain)
🕒 Full-time, 3-year position (start March 2026)
📅 Apply by Feb 15, 2026
👉 drive.google.com/file/d/1M8rp...

Join our virtual seminar!

@sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social

📅 Jan 8, 4pm UK
💻 Zoom

Register: us02web.zoom.us/webinar/regi...

#3DGenome #Epigenetics #ChromatinBiology

CAD-C reveals centromere pairing and near-perfect alignment of sister chromatids Three-dimensional (3D) genome organization plays a central role in gene regulation, chromatin folding, and genome stability. Although chromosome-conformation capture (3C)-derived methods have revoluti...

Hi all!
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.

www.biorxiv.org/content/10.6...

#3DGenome #chromatin #Cohesin #centromere

Hello everybody,
I am looking for an Engineer (IE) to help me start the lab at LBMC / ENS-Lyon in April.
We will investigate chromatin organization during replication in yeast.
RT appreciated!
To apply: inserm.softy.pro/offre/187863

@lbmcinlyon.bsky.social
#NewPI #3DGenome #chromatin #replication

Chromatin Architecture in Replication and Repair (CARR) — Laboratoire de Biologie et Modélisation de la Cellule Personal tools

Hi all !
Happy to share that I will open a lab at the LBMC at ENS-Lyon thanks to the #ATIP-Avenir funding.
We will investigate the role the 3D chromatin organization in Replication and Repair.

www.ens-lyon.fr/LBMC/equipes...


Job offers out soon!
#NewPI #3DGenome #chromatin #replication

⏪ G&D RECAP ⏪

🗓️ March 2025
RESEARCH PAPER: Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain
By Huang et al. and Wouter de Laat
➡️ https://genesdev.cshlp.org/content/39/5-6/348.full

#enhancer #3Dgenome #CTCF #TADs #chromatin

The emerging sequence grammar of 3D genome organisation - Human Genetics The multiplexed layers of regulatory processes and mechanisms within a cell are, to a degree, encoded in our genome. Unravelling the relationship between DNA sequence and molecular processes is crucia...

#WIMMReads: Researchers from the MRC Molecular Haematology Unit and the MRC WIMM Centre for Computational Biology review how #DNA sequence shapes the complex regulatory layers inside our cells.
Read more 👇

#Genomics
#3DGenome
#ComputationalBiology
@rdm.ox.ac.uk @medsci.ox.ac.uk

🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome

Postdoctoral Researcher in "Cancer Neuroscience: the impact of neural activity on 3D genome organization and cellular plasticity in glioblastoma”

Excited to share I’ve received a #SSMF #Consolidator grant!

📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics

🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM

Interested? Apply now 👇
rb.gy/m7xz7b

Welcome! You are invited to join a webinar: Sixth Annual Meeting on Advances on Nuclear Topology and 3D Chromatin Architecture in Cancer. After registering, you will receive a confirmation email about joining the webinar. This virtual symposium, supported by the National Cancer Institute (NIH-NCI), will focus on Advances in Nuclear Topology and 3D Chromatin Architecture in Cancer. Hosted jointly by NYU Langone Health and...

🧬 Register for the 6th Annual Conference on Nuclear Topology & 3D Chromatin Architecture in Cancer on Nov 25, 2025.
Speakers: Maeshima, Panne, Yost, Snuderl, Schmitt, Zhong, Ramani, Martínez, Hansen & Ren.
💻 Join for free: nyulangone.zoom.us/webinar/regi... #3Dgenome #CancerResearch #Chromatin

New study reveals 3D genome reorganization in Actinidia arguta, identifies AaCBP60B-like as key gene for anthocyanin regulation. #3DGenome #Anthocyanin #GeneDiscovery @oxfordacademic.bsky.social
Details: doi.org/10.1093/hr/u...

Synapse: Your Connection to our MSK Authors
Meet: Alexander Noor Shoushtari
Research Focus: Medicine; Associate Attending

Disruption of TAD hierarchy promotes LTR co-option in cancer
synapse.mskcc.org/synapse/work...

#CancerGenomics #3DGenome #TADs #LTR #TransposableElements

BandHiC: a memory-efficient and user-friendly Python package for organizing and analyzing Hi-C matrices down to sub-kilobase resolution. #3Dgenome #HiC #Python #Bioinformatics @biorxiv-bioinfo.bsky.social 🧬 🖥️
www.biorxiv.org/content/10.1...

Excited to present my poster, “A 3D Genome Framework for Causal Variant Fine-Mapping and Tissue-Specific Gene Regulation,” at @geneticssociety.bsky.social #ASHG2025 in Boston!

📌 Epigenetics Poster (Poster #8041F)
📅 Fri, Oct 17 | 2:30–4:30 PM EDT

#Genomics #Genetics #Epigenetics #3DGenome

Feeling inspired after presenting some #3Dgenome & #single-cell data at the #EDRC2025 in the beautiful #Alicante🇪🇸🧬🪰
Looking forward to the next amazing sessions to exchange ideas and connect with the community!

🧬Map Genome-wide chromatin-chromatin interactions using our Hi-C Service! 🔗 bit.ly/3VSs3DR

📖 Dive deeper into the science with our guide to understanding Hi-C and related methods: bit.ly/4pL34QT
_____________

#HiC #Epigenetics #3DGenome #Chromatin #Genomics #ActiveMotif #Research #Service

RESEARCH PAPER: Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
By Williamson et al.
➡️ https://tinyurl.com/gd352648

#chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion

📽️ G&D Tapes 📽️

G&D Author, Marion Solbach Mouginot tells us about their recent study in #genesdev describing how meta-domains control neuronal gene expression.

Learn more here:
➡️ bit.ly/45wGi5M

#TAD #chromatin #transcription #neuron #drosophila #3Dgenome

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...

🔬🧬 New in @natcomms.nature.com‬: Nanoscale 3D DNA tracing in non‑denatured cells maps the #3Dgenome at nm‑resolution and reveals Cohesin‑dependent dynamic loops! 🚀 #OpenAccess 

www.nature.com/articles/s41...

@ellenberglab.bsky.social @jungmannlab.bsky.social
#Genomics #SuperResolution