The 2026 AGBT General Meeting brought together many of the world’s leading genomics researchers, technology developers, investors, and industry leaders for several days of groundbreaking science, collaboration, and innovation.
👉 Watch the full recap video:
hubs.ly/Q046fjnL0
#AGBTGM26 #Genomics
Roche Axelios1 Run Pricing: Not A Knockout - Yet?
#AGBTGM26
🧬💻
omicsomics.blogspot.com/2026/03/roch...
Accelerate biological discovery with CartoScope presented at #AGBTGM26! Dive into 320+ spatial omics datasets straight from your browser with molecular-resolution inference. Read our pre-print at doi.org/10.5281/zeno... and Visit CartoScope at www.cartoscope.app
Ultima Genomics Solaris 2.0: Greater Version, Smaller Beads, Lose A Box
🧬💻
#AGBTGM26
omicsomics.blogspot.com/2026/03/ulti...
will be back at same site in Orlando next year, March 1-4, 2027
#AGBTGM26
Beth Shapiro and Len Pennacchio to make closing remarks.
That's it! Thanks for coming. Any feedback?
#AGBTGM26
TECHNOLOGY: Elinor Karlsson from @umasschan.bsky.social and @broadinstitute.org talks about new genomic approaches for exploring recent trait evolution in domestic pets at the 2026 AGBT General Meeting.
#AGBTGM26 #genomics #domestication
TECHNOLOGY: Job Dekker from @umasschan.bsky.social and Howard Hughes Medical Institute explored the mitotic inheritance of chromosome folding programs at the 2026 AGBT General Meeting.
#AGBTGM26 #Genomics #3DGenome
JO: DIstinct genomic compartmentalization of hypo- and hyper-methylation in cancer. Tumors share methylation states across distinct lineages. May be able to subtype cancers, use for liquid biopsy for tumor origin, identify cancer specific regulatory alterations
#AGBTGM26
JO: Are there conserved methylation across cancers or cancer-type profiles? Contaminating cell types can obscure patterns. Can deconvolve cell types.
#AGBTGM26
JO: see focal hypermethylation and global hypomethylation.
Cancer atlas has data on 450K sites, only 1-2% fo methylome. Can now do whole methyome. Looked at 106 tumors from 21 cancer types
#AGBTGM26
James Occean from Stanford will discuss whole genome profiling DNA methylation in primary tumors. Epigenetic alterations extensive in cancer
#AGBTGM26
YM: longer reads can be better assigned to maternal/paternal allele to see imprinting
#AGBTGM26
YM: use 5' kit and do long read 1. See extra cap G not genomically encoded in reads if goes all the way to 5' end. Do not see with premature termination to remove noise. See major start site but can also now see minor start sites previously hidden in noise
#AGBTGM26
Yasuhiro Murakawa from Kyoto talking about spatial transcriptomics technology for transcription start site profiling
#AGBTGM26
JB: another patient has main outlier at AS3MT, implicated in broad set of neuropsychiatric disorders. Depletion leads to increase in nerve, brain and muscle transcripts
#AGBTGM26
JB: Use CRISPR guides to remove highly expressed RNA. 400,000 guides made. See highly expressed genes go down, poorly expressed go up. Uncover novel splice sites as in KCNJ6 only identified in depletion
#AGBTGM26
JB: Of those with rare disease tested, 25-50% get a causal variant. RNAseq used to help interpret DNA mutations
#AGBTGM26
Jon Bezney from Stanford will talk about rare disease diagnostics especially using RNAseq
#AGBTGM26
TECHNOLOGY: @nevillesanjana.bsky.social from New York Genome Center and @nyupress.bsky.social discusses the massively-parallel approaches to understand the human noncoding genome and transcriptome at the 2026 AGBT General Meeting.
#AGBTGM26 #FunctionalGenomics #PrecisionMedicine
EK: you can sign up your pet for pets on the ark. Free to sign up, $150 if want to have sequenced
#AGBTGM26
EK: Are cats domestic? Yes, 4000 yrs ago: Evolution in response to an anthropogenic niche. A domestic population requires acces to that niche.
#AGBTGM26
EVOLUTIONARY GENOMICS: @tmarquesbonet.bsky.social from University Pompeu Fabra discusses the primate genomes as a model for biomedicine, evolution, and conservation at the 2026 AGBT General Meeting.
#AGBTGM26 #evolutionarygenomics
EK: Panagram counts kmers to compare genomes. very fast way to compare similarity. Highly correlated with Minimap
#AGBTGM26
EVOLUTIONARY GENOMICS: Dan Rokhsar from @ucberkeleyofficial.bsky.social discusses the deeply conserved synteny and the evolution of animals at the 2026 AGBT General Meeting.
#AGBTGM26 #evolutionarygenomics
EK: Can see trait effects on GWAS Howling associated with SCN3A. See many loci associated dog height. Very heretible.
#AGBTGM26
EK: 80% of current dogs are free roaming, living off human garbage just like 20,000 years ago. Dog breeds are only 150 years old. (Dirty secret: EK has never owned a dog). Behavioral traits are not fixed in breeds. Variability within breeds exceeds variability across breeds.
#AGBTGM26
