#Condensin II collaborates with #cohesin to establish and maintain #interphase #chromosome territories, say Takao Ono, Tatsuya Hirano (Riken) and colleagues: rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
In @jcb.org, Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Chromatin
Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
-Studies have shown that #Covid infection leads to the significant depletion of the #cohesin complex from specific regions within the genome called topologically associating domains (TADs).
through mechanisms including oxidative stress, disruption of DNA repair pathways & direct action of viral proteins.
🔑 mechanism invol the disruption of the #cohesin complex which alters genome structure , contributes to inflammation & cellular senescence, potentially playing a role in #longCOVID.
Hi all!
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.
www.biorxiv.org/content/10.6...
#3DGenome #chromatin #Cohesin #centromere
Epigenetics Update - Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation go.nature.com/3Me82WO
#Epigenetics #Cohesin #Chromatin
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Discover the breakthrough at epigenometech.com
🌟G&D SPOTLIGHT 🌟
REVIEW: Cohesin in 3D: development, differentiation, and disease
By Maria Solé-Ferran and Ana Losada
➡️ genesdev.cshlp.org/content/39/11-12/679.abs...
#cohesin #chromatin #chromosome #development #cohesinopathy
Epigenetics Update - Disentangling the architectural and non-architectural functions of CTCF and cohesin in gene regulation go.nature.com/488ztZx
#Epigenetics #CTCF #Chromatin #Cohesin
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Perfect for cancer, immunology, and aging research; epigenometech.com
Epigenetics Update - Characterization of induced cohesin loop extrusion trajectories in living cells go.nature.com/4762E09
#Epigenetics #Chromatin #Cohesin #ChromatinConformation #H3K27ac
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Gain deeper insights into gene regulation; epigenometech.com
How Cohesin Holds Sister Chromatids Together During DNA Replication
Cohesin rings encircle sister chromatids during DNA replication and are cleaved by separase in anaphase to allow chromosome separation. Read more: getnews.me/how-cohesin-holds-sister... #cohesin #celldivision
RESEARCH PAPER: Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
By Williamson et al.
➡️ https://tinyurl.com/gd352648
#chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion
![Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreiguzyelcl4wlmxfzvtzntffgkvnwjx4jr5ommoe7rgrg4askkmfru)
Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.
Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR
Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.
Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR
Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.
Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR
A chromatin remodeling-independent role for #ATRX in protecting centromeric cohesion –
Fangwei Wang and colleagues find an unexpected additional mechanism for preventing Wapl-mediated #cohesin release from mitotic centromere
www.embopress.org/doi/full/10....
How are architectural & epigenetic mechanisms of genome organization coordinated?
Jan-Michael Peters @impvienna.bsky.social et al show #cohesin mediates positioning of epigenetic reader Phf2 within the genome, affecting the size of heterochromatic B compartments
www.embopress.org/doi/full/10....
We are diving into 2025 with how we finished 2024: with great research. The lab of Jan-Michael Peters discovered how #cohesin not only drives #chromatin architecture, but also links it to #epigenetics. Now in @embojournal.bsky.social:
www.embopress.org/doi/full/10....
www.imp.ac.at/news/article...
One more video before Christmas: let our director Jan-Michael Peters tell you about his research on the organisation of #DNA by means of the IMP's dearest molecule - #cohesin. youtu.be/GbJCWpXu2f0
How do cohesin and CTCF control gene expression and what are their links to enhancers? Our new preprint unravels their shared and unique roles: from precise enhancer targeting to direct transcriptional activator functions of CTCF!
#Genomics #CTCF #Cohesin
www.biorxiv.org/content/10.1...
A new paper @ScienceMagazine shows that sister chromatid cohesion necessary for faithful cell division is mediated by individual #cohesin rings, supporting the ring model instead of handcuff model www.science.org/doi/10.1126/...
Online: our evolutionary interrogation of eukaryotic Structural Maintenance of Chromosomes (SMC) complexes @maxraas.bsky.social @eelcotromer.bsky.social @lauraeme.bsky.social #SMCcomplexes #eukaryogenesis #LECA #condensin #cohesin #evolutionarycellbiology #chromatin 🧵(1/6) doi.org/10.1101/2024...
