Pharmacological modulation of wakefulness and extracellular hypothalamic histamine release in adult male mice using TAK-925, modafinil, pitolisant, MK-8133 and Lu AF11167 Histamine is a key regulator of wake and arousal, however its role in pharmacological modulation of wake is largely unknown. Specifically, whether his…

Congrats to Camille Gylling Hviid on the first paper from her Industrial PhD 🎉 We paired EEG/EMG sleep scoring + hypothalamic histamine microdialysis across wake/sleep drugs and found histamine–wake coupling at baseline can decouple under drug drive. 👏 #SleepResearch #Neuroscience #industrialPhD

Opgaver | Kjartan Herrik Så ligger der Drughunters 2026 opgaver klar til vakse gymnasieelever, der vil prøve kræfter med at udvikle nye og bedre lægemidler til sygdomme i centralnervesystemet. Der er opgaver i biologi, biotek...

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Så ligger der Drughunters 2026 opgaver klar til vakse gymnasieelever, der vil prøve kræfter med at udvikle nye og bedre lægemidler til sygdomme i centralnervesystemet. Der er opgaver i biologi, biotek, kemi og matematik.

#opuspanelet #drughunters #brainbattle | Kjartan Herrik What a day! Drughunters and Brain Battle finalists outperformed this year! The highschool and master students that participated this year were super sharp and inspired eachother as well as me and my...

Always a pleasure to welcome young students participating in the Drughunters and Brain Battle competitions. Full of knowledge and great new ideas.

Thanks to #albergstrom for making this cover art for the Ascic et al paper. It portrays a person lost in dark thoughts. The prodrug strategy enables crossing the blood–brain barrier for a compound targeting the glycine site of the NMDA receptor (blue). Read the paper to learn more ...

The effect of ketamine and D-cycloserine on the high frequency resting EEG spectrum in humans - Psychopharmacology Rationale Preclinical studies indicate that high-frequency oscillations, above 100 Hz (HFO:100–170 Hz), are a potential translatable biomarker for pharmacological studies, with the rapid acting antide...

We show how high frequency oscillations ( #HFO ) in rats are induced by both #ketamine and glycine site partial agonists like #d-cycloserine/ #DCS and #AF90103. Something that we have also seen in healthy subjects (for ketamine and DCS).

Advancements in NMDA Receptor-Targeted Antidepressants: From d-Cycloserine Discovery to Preclinical Efficacy of Lu AF90103 The discovery of d-cycloserine (DCS), a partial agonist of the NMDA receptor that exhibits antidepressant effects without the psychotomimetic effects of ketamine, has fueled interest in new NMDA-targe...

We just published the interesting story of the making of an #NMDAR targeting compound that showed promising effects in preclinical models predicting anti-depressant effects. To get the compound into the brain we used a prodrug strategy.