📣 New Perspective out in @natcellbio.nature.com! With an interdisciplinary team of scientists, ethicists & lawyer we propose embedded ethics as a framework for navigating the complex ethics of human stem cell–based embryo models.

www.nature.com/articles/s41...

Free full text link: rdcu.be/fckmY

🧵

Honoring immigrants in research: The Vilcek Prizes in Biomedical Science Diverse voices overcome scientific challenges

Check out this article in @science.org featuring our Vilcek Prizewinners: @nucleosomepolice.bsky.social, @takashiakeralab.bsky.social, @amanglik.bsky.social, & @bernasozen.bsky.social! These immigrant scientists are shaping the future of medicine. Read more about their discoveries: vilcek.co/3OxUKFG

Transitions in development – an interview with Berna Sozen Berna Sozen is an Assistant Professor in the Department of Genetics at Yale University, USA. Berna's lab studies early mammalian development, metabolism, and maternal–fetal interactions using mouse an...

Good morning from Generative Biology! @bernasozen.bsky.social starts by taking a closer look at metabolism in early embryogenesis.

Learn more about stem cell-based embryo models in her recent @dev-journal.bsky.social Review: doi.org/10.1242/dev.... and interview: doi.org/10.1242/dev....

Really grateful to @bernasozen.bsky.social
and @harrymcnamara.bsky.social
for their thoughtful preview of our CRISPRa-programmed embryo model in @cp-cellstemcell.bsky.social. Love the title and the insight. means a lot to us!🙏🏾

Figure 2 Overview of cell state transitions in hPSCs in 2D and 3D embryo models. Embryo illustrations on the left represent the in vivo developmental stages corresponding to the three pluripotency states: naive (yellow), formative/intermediate (light green) and primed (dark green). On the right, the lineages they have the potential to give rise to in stem cell-based embryo models are illustrated. The generation of primordial germ cells (PGCs) from amnion remains to be determined. EXM, extra-embryonic mesoderm; PGCs, primordial germ cells.

In this Review, @bernasozen.bsky.social, Patrick Tam & Martin Pera summarize how recent studies of embryo models have advanced our understanding of cell state transitions of the pluripotent human epiblast and highlights some key remaining questions:
doi.org/10.1242/dev....

Pluripotent cell states and fates in human embryo models Summary: This Review summarizes how recent studies of embryo models have advanced our understanding of cell state transitions of the pluripotent human epiblast and highlights some key remaining questi...

a real pleasure to write this piece with Martin Pera and Patrick Tam, where we reflect on recent insights and open questions in early human development:

doi.org/10.1242/dev....

Get ready for our next western/evening 🌙 session seminar on Thursday!

with Loic Le-Goff @loic-legoff.bsky.social (buckling morphogenesis 🪰)

and Berna Sozen @bernasozen.bsky.social (🐁 gastrulation)

🗓️ Thursday, March 06th at
⏰ 09:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET

🚨Why can’t mammals regenerate legs or arms like frog tadpoles or salamanders?
Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing
🔗 www.biorxiv.org/content/10.1...
Happy New Year, everyone! 🎉
🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇

Metabolism is a key developmental regulator. In mammalian gastrulation, hexosamine biosynthetic pathway drives epiblast differentiation, while glycolysis guides mesoderm migration and lateral expansion.
bsky.app/profile/epim...